Psychophysical Assessment of Chemosensory Disorders in Clinical Populations

  • Claire Murphy
  • Judith A. Anderson
  • Stacy Markison


This chapter focuses on two groups in whom clinical problems of smell function occur: the very young and the old. The intent here is to examine several of these problems and their psychophysical manifestations and then to examine what this work reveals about normal function and psychophysical assessment.

Key words

Children Aging Dementia Nasal disease Odor threshold Odor identification 


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  1. 1.
    Doty RL, Shaman P, Dann M (1984) Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 32: 489–502PubMedCrossRefGoogle Scholar
  2. 2.
    Cain WS, Gent JS, Catalanotto FA, Goodspeed RB (1983) Clinical evaluation of olfaction. Am J Otolaryngol 4: 252–256PubMedCrossRefGoogle Scholar
  3. 3.
    Averback P (1983) Two new lesions in Alzheimer’s disease. Lancet 19: 1203CrossRefGoogle Scholar
  4. 4.
    Esiri MM, Wilcock GK (1984) The olfactory bulbs in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 47: 56–60PubMedCrossRefGoogle Scholar
  5. 5.
    Ohm TG, Braask H (1987) Olfactory bulb changes in Azheimer’s disease. Acta Neuropathol (Berl) 73: 365396Google Scholar
  6. 6.
    Reyes PF, Golden GT, Fagel PL, et al. (1987) The prepiriform cortex in dementia of the Alzheimer type. Arch Neurol 44: 644–645PubMedCrossRefGoogle Scholar
  7. 7.
    Waldton S (1974) Clinical observations of impaired cranial nerve function in senile dementia. Acta Psychiatr Scand 50: 539–547PubMedCrossRefGoogle Scholar
  8. 8.
    Serby M, Corwin J, Novatt A, Conrad P, Rotrosen J (1985) Olfaction in dementia. J Neurol Neurosurg Psychiatry 48: 848–849PubMedCrossRefGoogle Scholar
  9. 9.
    Warner MD, Peabody CA, Flattery JJ, Tinklenberg JR (1986) Olfactory deficits and Alzheimer’s disease. Biol Psychiatry 21: 116–118PubMedCrossRefGoogle Scholar
  10. 10.
    Koss E (1986) Olfactory dysfunction in Alzheimer’s disease. Dev Neuropsychol 2: 89–99CrossRefGoogle Scholar
  11. 11.
    Murphy C, Gilmore MM, Seery CS, Salmon DP, Lasker BR (1990) Olfactory thresholds are associated with degree of dementia in Alzheimer’s disease. Neurobiol Aging 11: 465–469PubMedCrossRefGoogle Scholar
  12. 12.
    Murphy C, Nordin S, de Wijk R, Cain WS, Polich J (1994) Olfactory evoked potentials: assessment of Psychophysical Assessment of Chemosensory Disorders young and elderly and comparison to psychophysical threshold. Chem Senses 19: 47–56PubMedCrossRefGoogle Scholar
  13. 13.
    Murphy C (1983) Age-related effects on the threshold, psychophysical function, and pleasantness of menthol. J Gerontol 38: 217–222PubMedCrossRefGoogle Scholar
  14. 14.
    Doty RL, Shaman P, Applebaum SL, et al. (1984) Smell identification ability: changes with age. Science 226: 1441–1443PubMedCrossRefGoogle Scholar
  15. 15.
    Murphy C, Cain WS, Gilmore MM, Skinner RB (1991) Sensory and semantic factors in recognition memory for odors and graphic stimuli: elderly versus young persons. Am J Psycho! 104: 161–192CrossRefGoogle Scholar
  16. 16.
    Schiffman SS (1986) Age related changes in taste and smell and their possible causes. In: Meiselman HL, Rivlin RS (eds) Clinical measurements of taste and smell. Macmillan, New York, pp 326–342Google Scholar
  17. 17.
    Murphy C (1986) Taste and smell in the elderly. In: Meiselman HL, Rivlin RS (eds) Clinical measurements of taste and smell. Macmillan, New York, pp 343–371Google Scholar
  18. 18.
    Murphy C (1989) Aging in chemosensory perception of and preference for nutritionally significant stimuli. In: Murphy C, Cain WS, Hegsted DM (eds) Nutrition and the chemical senses in aging: recent advances and current research needs. New York Academy of Sciences, New York, pp 251–266Google Scholar
  19. 19.
    Murphy C, Davidson TM (1992) Geriatric issues: special considerations. J Head Trauma Rehabil 7: 76–82CrossRefGoogle Scholar
  20. 20.
    Markison S, Murphy C (1993, submitted) Olfactory threshold comparison in young and elderly persons prescreened for nasal disease and dementiaGoogle Scholar

Copyright information

© Springer Japan 1994

Authors and Affiliations

  • Claire Murphy
    • 1
    • 2
  • Judith A. Anderson
    • 2
  • Stacy Markison
    • 1
  1. 1.Department of PsychologySan Diego State UniversitySan DiegoUSA
  2. 2.Division of Head and Neck SurgeryUniversity of California Medical Center San DiegoSan DiegoUSA

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