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Experimental Gastric Cancers

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Book cover Gastric Cancer

Abstract

Gastric cancer is still one of the most abundant cancers in the world, with high incidences generally related to low socioeconomical status. The intestinal type of adenocarcinoma of the stomach is associated with intestinal metaplasia resulting from chronic gastritis and is observed more frequently in Asian, Eastern European and South American countries. Some gastric cancers are related to atrophy of the mucosa in the fundus portion with involvement of pernicious anemia.

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References

  1. Sugimura T, Kawachi T (1973) Experimental stomach cancer. Methods in Cancer Res 7: 245–308

    CAS  Google Scholar 

  2. Mandell JO, Greenberg J (1960) A new chemical mutagen for bacteria, 1-methyl-3nitro-l-nitrosoguanidine. Biochem Biophys Res Commun 3: 575–577

    Article  PubMed  CAS  Google Scholar 

  3. Schoental R (1966) Carcinogenic activity of N-methyl-N’-nitro-N-nitrosoguanidine. Nature 209: 726–727

    Article  PubMed  CAS  Google Scholar 

  4. Sugimura T, Nagao M, Okada Y (1966) Carcinogenic action of N-methyl-N’-nitro-Nnitrosoguanidine. Nature 210: 962–963

    Article  PubMed  CAS  Google Scholar 

  5. Sugimura T, Fujimura S (1967) Tumor production in glandular stomach of rat by N-methyl-N’-nitro-N-nitrosoguanidine. Nature 216: 943–944

    Article  PubMed  CAS  Google Scholar 

  6. Sugimura T, Fujimura S, Baba T (1970) Tumor production in the glandular stomach and alimentary tract of the rat by N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Res 30: 455–465

    PubMed  CAS  Google Scholar 

  7. Saito T, Inokuchi K, Takayama S, Sugimura T (1970) Sequential morphological changes in N-methyl-N’-nitro-N-nitrosoguanidine carcinogenesis in the glandular stomach of rats. J Natl Cancer Inst 44: 769–783

    PubMed  CAS  Google Scholar 

  8. Matsukura N, Kawachi T, Sasajima K, Sano T, Sugimura T, Hirota T (1978) Induction of intestinal metaplasia in the stomachs of rats by N-methyl-N’-nitro-Nnitrosoguanidine. J Natl Cancer Inst 61: 141–144

    PubMed  CAS  Google Scholar 

  9. Correa P, Cuello C, Duque, E (1970) Carcinoma and intestinal metaplasia of the stomach in Columbian migrants. J Natl Cancer Inst 44: 297–306

    PubMed  CAS  Google Scholar 

  10. McCalla DR (1968) Reaction of N-methyl-N’-nitro-N-nitrosoguanidine and Nmethyl-N-nitroso-p-toluenesulfonamide with DNA in vitro. Biochim Biophys Acta 155: 114–120

    Article  PubMed  CAS  Google Scholar 

  11. Lawley PD, Shah SA (1970) Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N’-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen of guanine as a site of methylation. Biochem J 116: 693–707

    PubMed  CAS  Google Scholar 

  12. Weisburger JH, Jones RC, Barnes WS, Pegg AE (1988) Mechanisms of differential strain sensitivity in gastric carcinogenesis. Jpn J Cancer Res 79: 1304–1310

    Article  PubMed  CAS  Google Scholar 

  13. Sugimura T, Fujimura S, Nagao M, Yokoshima T, Hasegawa S (1968) Reaction of N-methyl-N’-nitro-N-nitrosoguanidine with protein. Biochim Biophys Acta 170: 427429

    Google Scholar 

  14. Bralow SP, Gruenstein M, Mevanze DR (1973) Host resistance to gastric adenocarcinomatosis in three strains of rats, ingesting N-methyl-N’-nitro-Nnitrosoguanidine. Oncology 27: 168–180

    Article  PubMed  CAS  Google Scholar 

  15. Ohgaki H, Tomihari M, Sato S, Kleiheus P, Sugimura T (1988) Differential proliferative response of gastric mucosa during carcinogenesis induced by N-methylN’-nitro-N-nitrosoguanidine in susceptible ACI rats, resistant Buffalo rats, and their F1 hybrid cross. Cancer Res 48: 5275–5279

    PubMed  CAS  Google Scholar 

  16. Fujimura S, Kogure K, Oboshi S, Sugimura T (1970) Production of tumors in the glandular stomach of hamsters by N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Res 30: 1444–1448

    PubMed  CAS  Google Scholar 

  17. Sugimura T, Tanaka N, Kawachi T, Kogure K, Fujimura S, Shimosato Y (1971) Production of stomach cancer in dogs by N-methyl-N’-nitro-N-nitrosoguanidine. Gann 62: 67

    PubMed  CAS  Google Scholar 

  18. Shimosato Y, Tanaka N, Kogure K, Fujimura S, Kawachi T, Sugimura T (1971) Histopathology of tumors of canine alimentary tract produced by N-methyl-N’-nitroN-nitrosoguanidine with particular reference to gastric carcinomas. J Natl Cancer Inst 47: 1053–1070

    PubMed  CAS  Google Scholar 

  19. Kurihara M, Shirakabe H, Murakami T, Yasui A, Izumi T, Sumida M, Igarashi A (1974) A new method for producing adenocarcinomas in the stomach of dogs with N-methyl-N’-nitro-N-nitrosoguanidine. Gann 65: 163–177

    PubMed  CAS  Google Scholar 

  20. Fujita M, Taguchi T, Takami M, Usugane M, Takahashi A (1975) Lung metastasis of canine gastric adenocarcinoma induced by N-methyl-N’-nitro-N-nitrosoguanidine. Gann 66: 107–108

    PubMed  CAS  Google Scholar 

  21. Sunagawa M, Takeshita K, Nakajima A, Ochi K, Kabu H, Endo M (1985) Duration of ENNG administration and its effect on histological differentiation of experimental gastric cancer. Br J Cancer 52: 771–779

    Article  PubMed  CAS  Google Scholar 

  22. Ohgaki H, Hasegawa H, Kusama K, Morino K, Matsukura N, Sato S, Maruyama K, Sugimura T (1986) Induction of gastric carcinomas in nonhuman primates by N-ethyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst 77: 179–186

    PubMed  CAS  Google Scholar 

  23. Szentirmay Z, Ohgaki H, Maruyama K, Esumi H, Takayama S, Sugimura T (1990) Early gastric cancer induced by N-methyl-N’-nitro-N-nitrosoguanidine in a cynomolugus monkey six years after initial diagnosis of the lesion. Jpn J Cancer Res 81: 6–9

    Article  PubMed  CAS  Google Scholar 

  24. Tatematsu M, Takahashi M, Fukushima S, Hananouchi M, Shirai T (1975) Effects in rats of sodium chloride on experimental gastric cancer induced by N-methyl-N’-nitroN-nitrosoguanidine or 4-nitroquinoline 1-oxide. J Natl Cancer Inst 55: 101–106

    PubMed  CAS  Google Scholar 

  25. Takahashi M, Kokubo T, Furukawa F, Kurokawa Y, Tatematsu M, Hayashi Y (1982) Effect of high salt diet on rat gastric carcinogenesis induced by N-methyl-N’nitro-N-nitrosoguanidine. Carcinogenesis 3: 1419–1422

    Article  Google Scholar 

  26. Ohgaki H, Kato T, Morino K, Matsukura N, Sato S, Takayama S, Sugimura T (1984) Study of the promoting effect of sodium chloride on gastric carcinogenesis by N-methyl-N’-nitro-N-nitrosoguanidine in inbred Wistar rats. Gann 75: 1053–1057

    PubMed  CAS  Google Scholar 

  27. Takahashi M, Okayama H, Furukawa F, Sato H, Hasegawa R, Shimoji N, Jang JJ, Hayashi Y (1988) Promoting effect of lower dose sodium chloride on rat gastric carcinogenesis. In: Proceedings of the Japanese Cancer Association, 47th Annual Meeting, Takyo, p 83

    Google Scholar 

  28. Sugimura T, Wakabayashi K (1990) Gastric carcinogenesis: Diet as a causative factor. Med Oncol Tumor Pharmacother 7: 87–92

    Google Scholar 

  29. Takahashi M, Hasegawa T, Furukawa F, Okamiya H, Shinoda K, Imaida K, Toyoda K, Hayashi Y (1991) Enhanced lipid peroxidation in rat gastric mucosa caused by NaCl. Carcinogenesis 12: 2201–2204

    Article  PubMed  CAS  Google Scholar 

  30. Hirose M, Kurata Y, Tsuda H, Fukushima S (1987) Catechol strongly enhances rat stomach carcinogenesis: A possible new environmental stomach carcinogen. Jpn J Cancer Res (Gann) 78: 1144–1149

    Google Scholar 

  31. Kobori O, Shimizu T, Maeda M, Atomi Y, Watanabe J, Shoji M, Morioka Y (1984) Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N-methylN’-nitro-N-nitrosoguanidine in Wistar rats. J Natl Cancer Inst 73: 853–861

    PubMed  CAS  Google Scholar 

  32. Salmon RJ, Merle S, Zafrani B, Decosse JJ, Sherlock P, Deschner EE (1985) Gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine: Role of gastrectomy and duodenal reflux. Jpn J Cancer Res (Gann) 76: 167–172

    Google Scholar 

  33. Furukawa H, Iwanaga T, Koyama H, Taniguchi H (1982) Effect of sex hormones on carcinogenesis in the stomachs of rats. Cancer Res 42: 5181–5182

    PubMed  CAS  Google Scholar 

  34. Furihata C, Sudo K, Matsushima T (1989) Calcium chloride inhibits stimulation of replicative DNA synthesis by sodium chloride in the pyloric mucosa of rat stomach. Carcinogenesis 10: 2135–2137

    Article  PubMed  CAS  Google Scholar 

  35. Nishikawa A, Furukawa F, Mitsui M, Enami T, Kawanishi T, Hasegawa T, Takahashi M (1992) Inhibitory effect of calcium chloride on gastric carcinogenesis in rats after treatment with N-methyl-N’-nitro-N-nitrosoguanidine and sodium chloride. Carcinogenesis 13: 1155–1158

    Article  PubMed  CAS  Google Scholar 

  36. Wang X, Williams GM (1987) Comparison of stomach cancer induced in rats by N-methyl-N’-nitro-N-nitrosoguanidine or N-propyl-N’-nitro-N-nitrosoguanidine. Cancer Lett 34: 173–185

    Article  PubMed  CAS  Google Scholar 

  37. Druckrey H, Ivankovic S, Preussmann R (1970) Selektiv Erzeugung von Carcinomen des Drüsenmagens bei Ratten durch Orale Gabe von N-Methyl-N-nitroso-N’acetylharnstoff ( AcMNH ). Z Krebsforsch 74: 22–33

    Google Scholar 

  38. Maekawa A, Matsuoka C, Onodera H, Tanigawa H, Furuta K, Ogiu T, Mitsumori K, Hayashi Y (1985) Organ-specific carcinogenicity of N-methyl-N’-nitro-Nnitrosourea in F344 and ACl/N rats. J Cancer Res Clin Oncol 109: 178–182

    Article  PubMed  CAS  Google Scholar 

  39. Hirota N, Aonuma T, Yamada S, Kawai T, Saito K, Yokoyama T (1987) Selective induction of glandular stomach carcinoma in F344 rats by N-methyl-N-nitrosourea. Jpn J Cancer Res (Gann) 78: 634–638

    CAS  Google Scholar 

  40. Ebihara K, Ekimoto H, Itchoda Y, Abe F, Inoue H, Aoyagi S, Yamashita T, Koyu A, Takahashi K, Yoshioka O, Matsuda A (1978) Studies on antitumor activities and pulmonary toxicity of pepleomycin sulfate (NK631) (in Japanese). Jpn J Antibiot 31: 872–885

    Article  PubMed  CAS  Google Scholar 

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© 1993 Springer Japan

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Sugimura, T. (1993). Experimental Gastric Cancers. In: Nishi, M., Ichikawa, H., Nakajima, T., Maruyama, K., Tahara, E. (eds) Gastric Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68328-5_3

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  • DOI: https://doi.org/10.1007/978-4-431-68328-5_3

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68330-8

  • Online ISBN: 978-4-431-68328-5

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