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Gastric Cancer pp 196–208Cite as

Oncogenes and Tumor Suppressor Genes

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Abstract

The proliferation of normal cells is regulated by the balance between the growth-promoting signals of proto-oncogenes and the growth-constraining signals of tumor suppressor genes [1, 2]. Multiple steps including initiation, promotion and progression are required for the conversion of normal cells to fully malignant cells with invasive and metastatic capacities. Multiple genetic changes, including activation of proto-oncogenes and inactivation of tumor suppressor genes, occurs during multi-step carcinogenesis which takes 20–30 years [3]. Gastric cancer is still one of the most common malignancies, not only in Japan, but also worldwide. Yet, there has been only limited information available on genetic changes in gastric cancer. In this chapter, all the available information on genetic changes in gastric cancer will be presented, and its perspectives will be discussed.

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Author information

Authors and Affiliations

  1. Genetics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104, Japan

    Masaaki Terada

Authors
  1. Masaru Katoh
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  2. Masaaki Terada
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Editor information

Editors and Affiliations

  1. Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo, 170, Japan

    Mitsumasa Nishi M.D.

  2. National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104, Japan

    Heizaburo Ichikawa M.D.

  3. Department of Surgery, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo, 170, Japan

    Toshifusa Nakajima M.D.

  4. Gastric Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104, Japan

    Keiichi Maruyama M.D.

  5. Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734, Japan

    Eiichi Tahara M.D.

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© 1993 Springer Japan

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Katoh, M., Terada, M. (1993). Oncogenes and Tumor Suppressor Genes. In: Nishi, M., Ichikawa, H., Nakajima, T., Maruyama, K., Tahara, E. (eds) Gastric Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68328-5_14

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  • DOI: https://doi.org/10.1007/978-4-431-68328-5_14

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68330-8

  • Online ISBN: 978-4-431-68328-5

  • eBook Packages: Springer Book Archive

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