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The Role of Hemodynamics in Atherogenesis

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Current Aspects of Blood Coagulation, Fibrinolysis, and Platelets

Abstract

In the aortic tree, atherosclerotic lesions are distributed preferentially in the branching and curved areas. In these lesion-prone areas, focal accumulation of lipid deposition has been detected in normal and atherosclerotic aortas by using radio-labeled low density lipoprotein (LDL) or Sudanophilic stain (1,2). These observations suggest the importance of hemodynamic factors (e.g., local wall shear stress) for atherogenesis, including the initiation, localization and progression of atherosclerosis.

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Author information

Authors and Affiliations

  1. Institute for Biomedical Engineering and Department of Applied Mechanics and Engineering Science, University of California, San Diego, La Jolla, California, 92093-0412, USA

    Kenji Sakakibara, Terue Sakakibara, Michael C. K. Chang & Shu Chien

  2. Department of Physiology, Hamamatsu University School of Medicine, Hamamatsu, 431-31, Japan

    Kenji Sakakibara

  3. Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, 431-31, Japan

    Terue Sakakibara

Authors
  1. Kenji Sakakibara
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  2. Terue Sakakibara
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  3. Michael C. K. Chang
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  4. Shu Chien
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Editor information

Editors and Affiliations

  1. Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

    Ming-Ching Shen (Professor and Chairman) (Professor and Chairman)

  2. Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan

    Che-Ming Teng (Professor and Chairman) (Professor and Chairman)

  3. Department of Physiology, School of Medicine, Hamamatsu University, 431-31, Hamamatsu, Shizuoka, Japan

    Akikazu Takada (Professor and Chairman) (Professor and Chairman)

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© 1993 Springer Japan

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Sakakibara, K., Sakakibara, T., Chang, M.C.K., Chien, S. (1993). The Role of Hemodynamics in Atherogenesis. In: Shen, MC., Teng, CM., Takada, A. (eds) Current Aspects of Blood Coagulation, Fibrinolysis, and Platelets. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68323-0_19

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  • DOI: https://doi.org/10.1007/978-4-431-68323-0_19

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-70123-1

  • Online ISBN: 978-4-431-68323-0

  • eBook Packages: Springer Book Archive

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