Abstract
Glycerol, which is a low molecular weight (92 g/mol) alcohol, may enter the brain at a very slow rate; therefore, its administration will raise blood osmolality and create an osmotic gradient between plasma and brain with resultant net removal of water from brain. Indeed, previous studies showed that it appears to be an effective cerebral dehydrating agent [1–5].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Absolon MJ (1966) Brit J Ophthalmol 59: 683–688
Buckell M, Walsh L (1964) Lancet 2: 1151–1152
Cantore GP, Guidetti B, Virno M (1965) J Neurosurg 21: 278–283
Mathew NT, Meyer JS, Rivera VM, Charney JZ, Hartmann A (1972) Lancet 2: 1327–1329
Newkirk TA, Tourtellotte WW, Reinglass JL (1962) Arch Neurol 27: 95–96
Okamoto S, Hijikata A, Kikumoto R, Tonomura S, Hara H, Ninomiya K, Maruyama A, Sugano M, Tamao Y (1981) Biochem Biophys Res Commun 101: 440–446
Kikumoto R, Tamao Y, Tezuka T, Tonomura S, Hara H, Ninomiya K, Hijikata A, Okamoto S (1984) Biochemistry 23: 85–90
Tamao Y, Yamato T, Hirata T, Kinugasa M, Kikumoto R (1986) Jpn Pharmacol Ther suppl 14: 869–874
Hara H, Tamao Y, Kikumoto K (1986) Jpn Pharmacol Ther suppl 14: 875–881
Green D, Ts’ao C-H, Reynolds N, Kahn H, Cohen I (1985) Thromb Res 37: 145–153
Esumi N, Todo S, Imashyuku S (1987) Cancer Res 47: 2129–2135
Kobayashi S, Kitani M, Yamaguchi S, Suzuki T, Okada K, Tsunematsu, T (1989) Thromb Res 53: 305–317
Hoylaerts M, Rijken DC, Lijken HR, Collen D (1982) J Biol Chem 257: 2912–2919
Matsuo O, Rijken DC, Collen D (1981) Thromb Haemost 45: 225–229
Hara T, Iwamoto M, Ogawa H, Yamamoto A, Tomikawa M (1990) Thromb Res 59: 703–712
Lowry OH, Rosebrough NJ, Farr AL, Randall, RJ (1951) J Biol Chem 193: 265–275
Shigeno T, Brock M, Shigeno S, et al. (1982) J Neurosurg 57: 99–107.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Japan
About this paper
Cite this paper
Tanabe, K., Honda, Y., Iwamoto, M. (1993). The Effect of Argatroban on the Ability of Glycerol to Inhibit Cerebral Edema and the Effect of the Co-Administration of Argatroban with t-PA and Heparin on Blleding Time. In: Shen, MC., Teng, CM., Takada, A. (eds) Current Aspects of Blood Coagulation, Fibrinolysis, and Platelets. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68323-0_12
Download citation
DOI: https://doi.org/10.1007/978-4-431-68323-0_12
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-70123-1
Online ISBN: 978-4-431-68323-0
eBook Packages: Springer Book Archive