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Possible Involvement of Platelet Activating Factor (PAF) in Tissue Factor Generation and the Pathogenesis of Disseminated Intravascular Coagulation (DIC)

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Current Aspects of Blood Coagulation, Fibrinolysis, and Platelets

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Abstract

PAF is a highly potent lipid mediator with diverse biological actions such as activation of platelets and leukocytes, induction of hypotension and bronchoconstriction (1). In earlier papers, we reported that PAF may play important roles in the pathogenesis of anaphylactic shock in mice and endotoxin shock and DIC in rats using the first PAF antagonist, CV-3988 (2–5).

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Author information

Authors and Affiliations

  1. Research on Research, Pharmaceutical Research Division (ZT) and Department II of Pharmaceutical Research Laboratories I (MK, YI and KN), Takeda Chemical Industries, Ltd., 17-85, Juso-Honmachi 2-chome, Yodogawa-ku, Osaka, 532, Japan

    Z. Terashita, M. Kawamura, Y. Imura & K. Nishikawa

Authors
  1. Z. Terashita
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  2. M. Kawamura
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  3. Y. Imura
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  4. K. Nishikawa
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Editor information

Editors and Affiliations

  1. Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

    Ming-Ching Shen (Professor and Chairman) (Professor and Chairman)

  2. Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan

    Che-Ming Teng (Professor and Chairman) (Professor and Chairman)

  3. Department of Physiology, School of Medicine, Hamamatsu University, 431-31, Hamamatsu, Shizuoka, Japan

    Akikazu Takada (Professor and Chairman) (Professor and Chairman)

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© 1993 Springer Japan

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Terashita, Z., Kawamura, M., Imura, Y., Nishikawa, K. (1993). Possible Involvement of Platelet Activating Factor (PAF) in Tissue Factor Generation and the Pathogenesis of Disseminated Intravascular Coagulation (DIC). In: Shen, MC., Teng, CM., Takada, A. (eds) Current Aspects of Blood Coagulation, Fibrinolysis, and Platelets. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68323-0_10

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  • DOI: https://doi.org/10.1007/978-4-431-68323-0_10

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-70123-1

  • Online ISBN: 978-4-431-68323-0

  • eBook Packages: Springer Book Archive

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