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Prevention of Hepatitis B Infection

  • Alfred M. Prince
  • Richard Mahoney
  • James Maynard

Abstract

The control of infectious diseases generally involves three successive steps: first, the identification of the etiologic agent, second, the development of means for interruption of transmission, and, lastly the utilization of these means. Tremendous progress has been made in the first two of the above steps during the past 30 years. Hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV) have been identified and characterized to the level of nucleotide sequence. Safe and effective HBV and hepatitis A virus (HAV) vaccines have been developed and licensed. Sensitive and specific screening assays are available for the identification of blood donors infected with HBV and HCV. As described elsewhere at this meeting, progress is being made towards development of vaccines for HDV and HEV. However, progress in the utilization of these measures on a worldwide basis has been disappointingly slow. Indeed, it has become evident that implementation of control measures is a problem of greater magnitude and complexity than the development of the vaccines to be used in control of the disease. This report will illustrate this problem in the context of HBV control, and will describe efforts being made to accelerate the rate of progress.

Key words

Prevention Hepatitis B virus Vaccine Utilization 

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References

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    Prince AM, Vnek J, Brotman B (1984) An affordable multideterminant plasma derived hepatitis B virus vaccine. Proceedings of the Symposium on Virus-Associated Cancers in Africa, Nairobi, IARC Scientific Publications, 63: 355–372Google Scholar
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    Mahoney RT (1990) Cost of plasma-derived hepatitis B vaccine production. Vaccine 8: 397–401PubMedCrossRefGoogle Scholar
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    Wang JY, Li RC, Wang SS, Xu ZY, Maynard JE, Ding ZR, Nong YZ (1993) A large-scale immunization against hepatitis B in Long An County, Guangxi, China (abstract). International Symposium on Viral Hepatitis and Liver Disease, 8th Triennial Congress, Scientific Program and Abstract Volume, p 163Google Scholar

Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Alfred M. Prince
    • 1
  • Richard Mahoney
    • 2
  • James Maynard
    • 2
  1. 1.The Laboratory of Virology and ParasitologyLindsley F. Kimball Research Institute of the New York Blood CenterNew YorkUSA
  2. 2.Program for Appropriate Technology in Health CareSeattleUSA

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