Angiotensin II Induced Hypertension Chemotherapy (IHC) for Advanced Gastric Carcinoma
Under angiotensin 11 (A II) induced hypertension in which the mean arterial blood pressure did not exceed 150 mmHg, blood flow in tumor tissue increased selectively, while not in normal tissues. A II induced hypertension chemotherapy(IHC) has been carried out since 1978. Two randomized controlled trials, using a combination regimen of ADM,5-FU and MMC for advanced gastric carcinoma, showed significant augmentation of anti-tumor effects without increase of side effects. Surgical and pathological down-staging was observed in stage IV cancer patients. Based on the functional characteristics of tumor microcirculation, IHC which is a system of selective enhancement of drug delivery to tumor, will be useful for patients with any malignant tumors.
Key Wordsinduced hypertension chemotherapy (IHC) selective enhancement of drug delivery tumor microcirculation gastric carcinoma
Unable to display preview. Download preview PDF.
- 3.Kjartansson I.(1976) Tumor microcirculation. An experimental study in rat with a comparison of different methods for estimation of tumor blood flow. Acta Chirurg Scand (suppl 471): 5–74.Google Scholar
- 7.Suzuki M, Hori K, Abe I, Saito S. and Sato H. (1978) Characteristic blood circulation in tumor tissue with reference to chemotherapy. Cancer and chemotherapy 5(suppl) : 77–80.Google Scholar
- 9.Sato H, Sato K, Sato Y, Asamura M, Kanamaru R, Sugiyama Z, Kitahara T, Wakui A, Suzuki M, Hori K, Abe I, Saito S. and Sato H. (1981) Induced hypertension chemotherapy of cancer patients by selective enhancement of drug delivery to tumor tissue with angiotensin II. Sci Rep Res Inst, Tokoku Cniv Ser-C 28: 32–44.Google Scholar
- 10.Sato H, Sato K, Sato Y, Mimata Y, Asamura M, Kanamaru R, Wakui A, Suzuki M and Sato H. (1980) Clinical study on selective enhancement of drug delivery by angiotensin II in cancer chemotherapy. In: Metastasis, clinical and experimental aspect. Hellmann K, Hillgard P. and Eccles S.(eds). Martinus Nijhoff Publishers, The Hague, pp388–394.Google Scholar
- 11.Sato H, Sato K, Sato Y, Asamura M, Kanamaru R, Mimata Y. and Wakui A. (1981) Clinical cancer chemotherapy based on the experimental findings of selective enhancement of drug delivery to tumor tissue by angiotensin II. Jpn J Cancer Chemother 8(suppl) : 91–100.Google Scholar
- 13.Suzuki M, Hori K, Saito S.Tanda S, Abe I. Sato H. and Sato H. (1989) Functional characteristics of tumor vesse1s:Se1ective increase in tumor blood flow. Sci Rep Res Inst,Tokoku Univ Ser-C 36: 37–45.Google Scholar
- 14.Hoshi M. (1988) Increase of blood flow in human tumors under angiotensin II induced hypertension. Kosankinbyo Kenkyusyo Zasshi 40: 41–52.Google Scholar
- 15.Ishizuka K. (1993) DDS(in press).Google Scholar
- 18.Urushiyama M. (1990) Growth inhibition of micrometastases in the liver and angiotensin II induced hypertension chemotherapy (IHC).Kosankinbyo Kenkyusho Zasshi 42:133–144.Google Scholar
- 19.Sugiyama K. (1990) Selective enhancement of drug delivery to the peritoneal tumor and angiotensin II induced hypertension. Kosankinbyo Kenkyusho Zasshi 42: 145–159.Google Scholar
- 23.Sato H, Hoshi M, Wakui A. (1986) Clinical study on angiotensin induced hypertension chemotherapy (IHC). Jpn J Cancer Chemother 13:1439–1447.Google Scholar
- 24.Sato H, Wakui A, Hoshi M, Kurihara M, Yokoyama M. and Shimizu H.(1991) Randomized controlled trial of induced hypertension chemotherapy (IHC) using angiotensin II human(TY-10721) in advanced gastric carcinoma. (TY-10721 IHC Study Group Report). Jpn J Cancer Chemother 18:451–460.Google Scholar