Angiotensin II Induced Hypertension Chemotherapy (IHC) for Advanced Gastric Carcinoma

  • Haruhiko Sato
  • Katsuo Sugiyama
  • Keiichi Ishizuka
  • Masahiko Hoshi
  • Masanobu Urushiyama
  • Maroh Suzuki
Conference paper


Under angiotensin 11 (A II) induced hypertension in which the mean arterial blood pressure did not exceed 150 mmHg, blood flow in tumor tissue increased selectively, while not in normal tissues. A II induced hypertension chemotherapy(IHC) has been carried out since 1978. Two randomized controlled trials, using a combination regimen of ADM,5-FU and MMC for advanced gastric carcinoma, showed significant augmentation of anti-tumor effects without increase of side effects. Surgical and pathological down-staging was observed in stage IV cancer patients. Based on the functional characteristics of tumor microcirculation, IHC which is a system of selective enhancement of drug delivery to tumor, will be useful for patients with any malignant tumors.

Key Words

induced hypertension chemotherapy (IHC) selective enhancement of drug delivery tumor microcirculation gastric carcinoma 


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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Haruhiko Sato
    • 1
  • Katsuo Sugiyama
    • 1
  • Keiichi Ishizuka
    • 1
  • Masahiko Hoshi
    • 1
  • Masanobu Urushiyama
    • 1
  • Maroh Suzuki
    • 1
  1. 1.Department of Clinical Cancer Chemotherapy and Department of Experimental Oncology, The Research Institute for Cancer and TuberculosisTohoku UniversitySendai, 980Japan

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