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Hepatocellular Carcinoma: Hepatic Resection Versus Transplantation

  • Juan R. Madariaga
  • Rick Selby
  • Shunzaburo Iwatsuki
  • Brian Carr
  • Thomas E. Starzl
Conference paper

Abstract

From 1980 to 1989,76 patients with hepatocellular carcinoma were treated by subtotal hepatic resection (HX) and 105 by orthotopic liver transplantation (TX). The overall 1 to 5 year survival rates of the HX group were 71.1%, 55.0%, 47.2%, 37.2% and 32.9% respectively, and those of the TX group were 65.7%, 49.0%, 39.2%, 35.6% and 35.6%, respectively. The survival was similar stage by stage in both groups and correlated well with the pTNM classification. Tumor recurrence was high in both groups after HX (50%) and TX (43%) particularly in stages IV-A (≥ 60%). Twelve patients after HX and 13 patients after TX lived more than 5 years.

Keywords

TNM classification and hepatocellular carcinoma 

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References

  1. 1.
    Iwatsuki S, Starzl TE. Personal experience with 411 hepatic resections. Ann Surg 1988; 208:421–434.PubMedCrossRefGoogle Scholar
  2. 2.
    Bismuth H, Houssin D, Ornowski J, Meriggi F. Liver resection in cirrhotic patients: a Western experience. World J Surg 1986;10:311–317.PubMedCrossRefGoogle Scholar
  3. 3.
    Lin TY, Chen KM, Chen CC. Role of surgery in the treatment of primary carcinoma of the liver: a 21-year experience. Br J Surg 1987; 74:839–842.PubMedCrossRefGoogle Scholar
  4. 4.
    Nagasue N, Yukaya K, Ogawa Y, Sasaki Y, Chang Y and Niimi K. Clinical experience with 118 hepatic resections for hepatocellular carcinoma. Surgery 1986; 99:694.PubMedGoogle Scholar
  5. 5.
    Yamanaka N, Okamato E, Toyosaka A, Mitunobu M, Fujihara S, Kato T, Fujimoto J, Oriyama T, Furukawa K and Kawamura E. Prognostic factors after hepatectomy for hepatocellular carcinoma. Cancer 1990; 65:1104.PubMedCrossRefGoogle Scholar
  6. 6.
    Iwatsuki S, Starzl TE, Sheahan MB, Yokoyama H, Demetris AJ, Todo S, Tzakis AG, Van Thiel DH, Carr B, Selby R and Madariaga J. Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg, 1991; 221–223.Google Scholar
  7. 7.
    American Joint Committee on Cancer. Manual for Staging of Cancer, 3rd Edition. Philadelphia: JB Lippincott, 1987, pp 87–92.Google Scholar

Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Juan R. Madariaga
    • 1
  • Rick Selby
    • 1
  • Shunzaburo Iwatsuki
    • 1
  • Brian Carr
    • 1
  • Thomas E. Starzl
    • 1
  1. 1.Pittsburgh Transplant InstituteUniversity of Pittsburgh Medical CenterPittsburghUSA

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