Abstract
To enhance the therapeutic effects of liposomal adriamycin (Lip-ADM) for cancer treatment, lentinan (LNT), which is known to increase the permeability of vessels, was administered peritumorally prior to systemic administration of Lip-ADM and the therapeutic effects of Lip-ADM with LNT were investigated by using a xenotransplanted human colon cancer strain. The ADM levels of the tumor tissue in mice treated by the Lip-ADM with LNT were significantly higher than in those without LNT. The significant therapeutic effects of Lip-ADM with LNT were demonstrated by the evaluation of the tumor growth curve and actual tumor weights.
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© 1993 Springer-Verlag Tokyo
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Konno, H., Maruo, Y., Tanaka, T., Nakamura, S., Baba, S. (1993). The Therapeutic Effects of Liposomal Adriamycin Pretreated with Lentinan. In: Takahashi, T. (eds) Recent Advances in Management of Digestive Cancers. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68252-3_211
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DOI: https://doi.org/10.1007/978-4-431-68252-3_211
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68254-7
Online ISBN: 978-4-431-68252-3
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