Evaluation of Early Detection and Treatment of Hepatocellular Carcinoma

  • Zhao-You Tang
  • Ye-Qin Yu
  • Bing-Hui Yang
  • Xin-Da Zhou
  • Zhi-Ying Lin
  • Ji-Zhen Lu
  • Zhen-Chen Ma


During 1972–1991, 1443 patients with hepatocellular carcinoma (HCC) were studied. Comparison between screening (n=522) and nonscreening (n=921) groups revealed higher small HCC percentage (49.4% vs. 12.4%), higher resection rate (75.10% vs 45.9%) higher 5-year survival (42.1% vs. 24.8%) and bigger number of 5-year survivors (71 vs. 53). The increase of series 5-year survival (11.5% in 1970s to 43.4% in 1980s) coincided to the increase of screening in the series (25.3% to 41.2%). The increase of 5-year survival in screening group (29.0% in 1970s to 47.4% in 1980s) was a result of increasing resectability. The 5-year survival of 391 patients with subclinical HCC after resection was as high as 60.5%. It is concluded that screening using AFP and/or ultrasonography in high risk population and treated with resection is of proved merit to improve survival of patients with HCC.

Key Words

hepatocellular carcinoma screening alphafetoprotein subclinical hepatocellular carcinoma small hepatocellular carcinoma 


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Copyright information

© Springer-Verlag Tokyo 1993

Authors and Affiliations

  • Zhao-You Tang
    • 1
  • Ye-Qin Yu
    • 1
  • Bing-Hui Yang
    • 1
  • Xin-Da Zhou
    • 1
  • Zhi-Ying Lin
    • 1
  • Ji-Zhen Lu
    • 1
  • Zhen-Chen Ma
    • 1
  1. 1.Liver Cancer InstituteShanghai Medical UniversityShanghaiChina

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