Abstract
Laminin receptor ligand (laminin or YIGSR:synthetic laminin pentapeptide) was injected intraperitoneally into Ehrlich ascites tumor-bearing mice. The group receiving laminin only showed a shorter survival time than the group receiving tumor cells only. The injection of laminin with mitomycin C resulted in a longer survival time than mitomycin C inoculation alone. In the scanning electron-microscopic study, the mice injected with a single dose of laminin were observed to have many implanted cells. On the other hand, the laminin with mitomycin C group showed fewer implanted cells. YIGSR had no effect.
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References
Liotta LA, Rao CN, Wewer UN, (1986) Biochemicalinteractions of tumor cells with the basement membrane. Ann Rev Biochem 55:1037–1057
Yamamoto A, Fujimura M (1991) Degradation of peritoneal basement membrane by metastasizing tumor cells-An immunoelectronmicroscopic study-. Acta Histochem Cytochem 24:285–294
Rahman A, Panneerselvam M, Guirguis R, Castronova V, Sobel ME, Abraham K, Daddona PE, Liotta LA (1989) Anti-lamininreceptor antibody targeting of liposomes with encapsulated doxorubicin to human breat cancer cells in vitro. J Natl Cancer Inst 81:1794-1800
Albini A, Melchiori M, Santi L, Liotta LA, Brown PD, Stetlerstevenson WG (1991) Tumor cell invasion inhibited by TIMP-2. J Natl Cancer Inst 83:775–779
McCarthy JB, Furcht LT (1984) Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro. J CELL Biol 98:1474–1480
Wewer UN, Taraboletti G, Sobel ME, Albrechtsen R, Liotta LA (1987) Role of laminin receptor in tumor cell migration.CancerRes 47:5691–5698
Terranova VP, Williams JE, Liotta LA, Martin GR (1984) Modulation of the metastatic activity of melanoma cells by laminin an fibronectin. Science 226:982–985
Graf J, Iwamoto Y, Sasaki M, Martin GR, Kleinman HK, Robey FA, Yamada Y (1987) Identificaionof an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell 48:989–996
Iwamoto Y, Robey FA, Graf J, Sasaki M, Kleinman HK, Yamada Y, Martin GR (1987) YIGSR, a synthetic lamininpentapeptide, inhibits experimentalmetastasis formation. Science 238:1132–1134
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© 1993 Springer-Verlag Tokyo
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Yamamoto, A., Fujimura, M., Hirano, M., Suwo, M., Mori, A. (1993). Effect of Laminin Receptor Ligands on Peritoneal Metastasis. In: Takahashi, T. (eds) Recent Advances in Management of Digestive Cancers. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68252-3_115
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DOI: https://doi.org/10.1007/978-4-431-68252-3_115
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68254-7
Online ISBN: 978-4-431-68252-3
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