Summary
A method consisting of repeated 2 min coronary occlusions every 1 h, 8 h/day, 5 days/week, developed in Dean Franklin’s laboratory, allowed a quantitative evaluation of the speed of collateral growth and possible effects of some drugs on the rate of collateralization. In this canine model, the total occlusion number needed for the development of collateral circulation is an index of stimuli for collateralization.
The experimentally-identified characteristics of heparin to potentiate the mitogenic activity of ischemia-related fibroblast growth factors have been extended to the clinical setting as a possible therapeutic modality of modulating the collateral development in patients with coronary artery disease such as chronic effort angina and acute myocardial infarction.
Although these clinical studies have been conducted in small cohorts of patients, in nonrandomized and non-blinded methods, there is a possiblity that ischemic heart disease could be treated with drugs to potentiate the growth of collateral vessels. The development of such a therapeutic remedy would reduce the deleterious sequelae caused by coronary atherosclerosis.
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References
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© 1993 Springer-Verlag Tokyo
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Fujita, M., Sasayama, S. (1993). Potentiation of Collateral Development in Ischemic Patients with Heparin Treatment. In: Maruyama, Y., Kajiya, F., Hoffman, J.I.E., Spaan, J.A.E. (eds) Recent Advances in Coronary Circulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68249-3_30
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DOI: https://doi.org/10.1007/978-4-431-68249-3_30
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