Abstract
Nitroglycerin (GTN) has been widely used as an antianginal agent for more than a century. However, the exact mechanism of the effect of GTN is still uncertain and, in some aspect, controversial. A majority believes that GTN reduces myocardial wall tension by lowering preload and afterload due to dilation of capacitance vessels and this improves the the transmural distribution of the blood flow to the subendocardial layer of the myocardium [1, 2]. Brown et al.[3] clearly showed by angiography that GTN increases the luminal area in both normal and diseased portions of epicardial large coronary arteries, and concluded that vasodilation of epicardial coronary stenosis is usually a major component of the beneficial response to GTN. But they have not ruled out the role of venodilation.
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© 1992 Springer-Verlag Tokyo
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Nonaka, K., Ueno, A. (1992). Systemic Study of the Hemodynamic Effects of Nitroglycerin in Conscious Dogs: New Aspect of Mechanism of its Antianginal Action. In: Yasuda, H., Kawaguchi, H. (eds) New Aspects in the Treatment of Failing Heart. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68219-6_32
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DOI: https://doi.org/10.1007/978-4-431-68219-6_32
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68221-9
Online ISBN: 978-4-431-68219-6
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