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The role of HBV in hepatocellular carcinoma

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Primary Liver Cancer in Japan

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Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The incidence of HCC is particularly high in Africa [1, 2] and Asia [3-6]. There is apparently strong epidemiological evidence for an important role of hepatitis B virus (HBV) in the pathogenesis of HCC. However, the precise mechanism by which HBV infection might lead to malignant transformation of hepatocytes is still far from clear.

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References

  1. Vogel CL, Anthony PP, Mody N, Barker LF 1970 ) Hepatitis-associated antigen in Ugandan patients with hepatocellular carcinoma. Lancet 2: 621–624

    Article  PubMed  CAS  Google Scholar 

  2. Kew MC, Geddes EW, Macnab GM, Bersohn I (1974) Hepatitis-B antigen and cirrhosis in Bantu patients with primary liver cancer. Cancer 34: 539–541

    Article  Google Scholar 

  3. Beasley RP (1982) Hepatitis B virus as the etiologic agent in hepatocellular carcinoma—Epidemiologic considerations. Hepatology 2: 21s–26s

    Google Scholar 

  4. Gibson JB, Wu PC, Ho JCI, Lauder JJ (1980) HBsAg hepatocellular carcinoma and cirrhosis in Hong Kong. A necropsy study. Br J Cancer 42: 370–377

    Article  PubMed  CAS  Google Scholar 

  5. Prince AM, Szmuness W, Michon J, Desmaille J, Diebolt G, Linhard J, Quenum C, Sankale M (1975) A case-control study of the association between primary liver cancer and hepatitis B infection in Senegal. Int J Cancer 16: 376–383

    Article  PubMed  CAS  Google Scholar 

  6. Ligao AL, Domingo EO, Nishioka T (1981) Hepatitis B profile of hepatocellular carcinoma in the Philippines. Cancer 48: 1590–1595

    Article  Google Scholar 

  7. The Liver Cancer Study Group of Japan (1990) Primary liver cancer in Japan: Clinicopathologic features and results of surgial treatment. Ann Surgery 211: 277–287

    Google Scholar 

  8. Kuo G, Choo QL, Alter HJ, Gitnick GL, Redecker AG, Purcell RH, Miyamura T, Dienstag JL, Alter MJ, Stevens CE, Tegtmeier GF, Bonino F, Colombo M, Lee WE, Kuo C, Berger K, Shuster JR, Overby LR, Bradley DW, Houghton M (1989) An assay for circulating antibodies to a major etiologic virus of non-A, non-B hepatitis. Science 244: 362–364

    Article  PubMed  CAS  Google Scholar 

  9. Trichopoulos D, Day NE, Kaklamani E, Tzonou A, Munoz N, Zavitsanos X, Koumantaki Y, Trichopoulou A (1987) Hepatitis B virus, tobacco smoking and ethanol consumption in the etiology of hepatocellular carcinoma. Int J Cancer 39: 45–49

    Article  PubMed  CAS  Google Scholar 

  10. Austin H, Delzell E, Grufferman S, Levine R, Morrison AS, Stolly PD, Cole P (1986) A casecontrol study of hepatocellular carcinoma and the hepatitis B virus, cigarette smoking, and alcohol consumption. Cancer Res 46: 962–966

    PubMed  CAS  Google Scholar 

  11. Johnson PK, Krasner N, Portmann B, Eddleston ALWF, Williams R (1978) Hepatocellular carcinoma in Great Britain: Influence of age, sex, HBsAg status and etiology of underlying cirrhosis. Gut 19: 1022–1026

    Article  PubMed  CAS  Google Scholar 

  12. Adrian MD (1988) Hepatocellular carcinoma. Ann Intern Med 108: 390 - 401

    Google Scholar 

  13. Health and Welfare Statistics Association (1990) The trend of the national health and welfare in 1990 (in Japanese). J Health Welfare Statistics 37: 58–59

    Google Scholar 

  14. The Liver Cancer Study Group of Japan (1984) Primary liver cancer in Japan. Cancer 54: 1747–1755

    Article  Google Scholar 

  15. The Liver Cancer Study Group of Japan (1987) Primary liver cancer in Japan. Cancer 60: 1400–1411

    Article  Google Scholar 

  16. Omata M, Ashcavai M, Liew CT, Peters R (1979) Hepatocellular carcinoma in the USA: Etiologic considerations. Gastroenterology 76: 279–287

    PubMed  CAS  Google Scholar 

  17. Zur Hausen H (1986) Intracellular surveillance of persisting viral infection. Lancet 2: 489–491

    Article  PubMed  Google Scholar 

  18. Ferenci P, Dragosics B, Morosi L, Kiss F (1984) Relative incidence of primary liver cancer in cirrhosis in Austria: Etiological consideration. Liver 4: 7–14

    PubMed  CAS  Google Scholar 

  19. Brechot C, Pourcel C, Louise A, Rain B, Tiollais P (1980) Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 286: 533–535

    Article  PubMed  CAS  Google Scholar 

  20. Rogler CE, Sherman M, Su CY, Shafritz DA, Summers J, Show TB, Henderson H, Kew M (1985) Deletion in chromosome l i p associated with a hepatitis B integration site in hepatocellular carcinoma. Science 230: 329–332

    Article  Google Scholar 

  21. Hino O, Shows TB, Roger CE (1986) Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17; 18 translocation. Proc Natl Acad Sei USA 83: 8338–8342

    Article  CAS  Google Scholar 

  22. Dejean A, Bougueleret L, Grzeschik KH, Tiollas P (1986) Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature 322: 70–72

    Article  PubMed  CAS  Google Scholar 

  23. Yaginuma K, Kobayashi M, Yoshida E, Koike K (1987) Hepatitis B virus integration in hepatocellular carcinoma DNA: Duplication of cellular flanking sequences at the integration site. Proc Natl Acad Sei USA 82: 4452–4462

    Article  Google Scholar 

  24. Benbrook D, Lernhardt E, Pfahl M (1988) A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature 333: 669–672

    Article  PubMed  CAS  Google Scholar 

  25. Shafrits DA, Shouval D, Sherman (1981) Integration of hepatitis B DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. N Engl J Med 305: 1067–1073

    Article  Google Scholar 

  26. Kam W, Rail LB, Smuckler EA, Schmid R, Rutter WJ (1982) Hepatitis B viral DNA in liver and serum of asymptomatic carriers. Proc Natl Acad Sei USA 79: 7522–7526

    Article  CAS  Google Scholar 

  27. Two JS, Schloemer RH (1987) Trans criptiona trans-activating function of hepatitis B virus. J Virol 61: 3448–3453

    Google Scholar 

  28. Summers J, Manson WS (1982) Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29: 403–415

    Article  PubMed  CAS  Google Scholar 

  29. Chisari FV, Klopchin K, Moriyama T, Pasquinell C, Dunsford HA, Sell S, Pinkert CA, Brinster RL, Palmiter RD (1989) Molecular pathogenesis of hepatocellular carcinoma in Hepatitis B virus transgenic mice. Cell 59: 1145–1158

    Article  PubMed  CAS  Google Scholar 

  30. Toh H, Hayashida H, Miyata T (1983) Sequence homology between retroviral transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus. Nature 305: 827–829

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Tokyo Metropolitan Komagome Hospital, 113, Komagome, Bunkyo-ku Tokyo, Japan

    Satoshi Tanaka & Nobu Hattori

Authors
  1. Satoshi Tanaka
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  2. Nobu Hattori
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Editor information

Editors and Affiliations

  1. 1st Department of Surgery, Faculty of Medicine, Kyoto University, 54-Shogoin Kawara-cho, 606, Sakyo-ku, Kyoto, Japan

    Takayoshi Tobe M. D. (Chairman and Professor) (Chairman and Professor)

  2. The First Department of Internal Medicine, Jikei University School of Medicine, 105, Minato-ku, Tokyo, Japan

    Haruo Kameda

  3. Department of Pathology, School of Medicine, Kitasato University, 228, Sagamihara, Japan

    Masahiko Okudaira

  4. First Department of Medicine, School of Medicine, Chiba University, 280, Chiba, Japan

    Masao Ohto

  5. Sanraku Hospital, 2-5 Kanda Surugadai, 101, Chiyoda-ku, Tokyo, Japan

    Yasuo Endo

  6. The Second Department of Surgery, Asahikawa Medical College, Nishikagura 4-5, 078, Asahikawa, Hokkaido, Japan

    Michio Mito

  7. The First Department of Surgery, Hyogo College of Medicine, 663, Nishinomiya, Hyogo, Japan

    Eizo Okamoto

  8. Second Department of Medicine, Kurume University School of Medicine, 830, Kurume, Japan

    Kyuichi Tanikawa

  9. First Department of Pathology, Kurume University School of Medicine, 830, Fukuoka, Japan

    Masamichi Kojiro

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© 1992 Springer-Verlag Tokyo

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Tanaka, S., Hattori, N. (1992). The role of HBV in hepatocellular carcinoma. In: Tobe, T., et al. Primary Liver Cancer in Japan. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68177-9_7

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  • DOI: https://doi.org/10.1007/978-4-431-68177-9_7

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68179-3

  • Online ISBN: 978-4-431-68177-9

  • eBook Packages: Springer Book Archive

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