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Hepatocellular carcinoma in the early stage

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Book cover Primary Liver Cancer in Japan

Abstract

Progress in imaging diagnosis has made it possible to detect an increasing number of minute hepatocellular carcinomas (HCCs), some of which can be removed successfully by surgery. In addition, lesions intermediate between regenerative nodules and minute HCCs, i.e. borderline lesions, can also be detected. Through analysis of these lesions, we have learned the natural course of human hepatocarcinogenesis. Long after infection with hepatitis viruses, small nodular lesions (adenomatous hyperplasia), which do not destroy substantially the underlying liver structure, develop in liver showing chronic hepatitis or cirrhosis. Some of these nodules show structural abnormalities and are diagnosed as well-differentiated HCC (early HCC). Nodule-in-nodule lesions composed of a peripheral area of early HCC and a central area of less well differentiated HCC are also observed. Clinicopathologically, it is very important to establish criteria for differentiating between adenomatous hyperplasia and early HCC.

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Author information

Authors and Affiliations

  1. Pathology Division, National Cancer Center Research, Institute, 104, Tsukiji, Chuo-ku, Tokyo, Japan

    Setsuo Hirohashi & Michiie Sakamoto

Authors
  1. Setsuo Hirohashi
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  2. Michiie Sakamoto
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Editor information

Editors and Affiliations

  1. 1st Department of Surgery, Faculty of Medicine, Kyoto University, 54-Shogoin Kawara-cho, 606, Sakyo-ku, Kyoto, Japan

    Takayoshi Tobe M. D. (Chairman and Professor) (Chairman and Professor)

  2. The First Department of Internal Medicine, Jikei University School of Medicine, 105, Minato-ku, Tokyo, Japan

    Haruo Kameda

  3. Department of Pathology, School of Medicine, Kitasato University, 228, Sagamihara, Japan

    Masahiko Okudaira

  4. First Department of Medicine, School of Medicine, Chiba University, 280, Chiba, Japan

    Masao Ohto

  5. Sanraku Hospital, 2-5 Kanda Surugadai, 101, Chiyoda-ku, Tokyo, Japan

    Yasuo Endo

  6. The Second Department of Surgery, Asahikawa Medical College, Nishikagura 4-5, 078, Asahikawa, Hokkaido, Japan

    Michio Mito

  7. The First Department of Surgery, Hyogo College of Medicine, 663, Nishinomiya, Hyogo, Japan

    Eizo Okamoto

  8. Second Department of Medicine, Kurume University School of Medicine, 830, Kurume, Japan

    Kyuichi Tanikawa

  9. First Department of Pathology, Kurume University School of Medicine, 830, Fukuoka, Japan

    Masamichi Kojiro

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© 1992 Springer-Verlag Tokyo

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Hirohashi, S., Sakamoto, M. (1992). Hepatocellular carcinoma in the early stage. In: Tobe, T., et al. Primary Liver Cancer in Japan. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68177-9_3

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  • DOI: https://doi.org/10.1007/978-4-431-68177-9_3

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68179-3

  • Online ISBN: 978-4-431-68177-9

  • eBook Packages: Springer Book Archive

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