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Neurotransmitter Changes in Hydrocephalus: Effects of Cerebral Metabolic Activator on Kaolin-Induced Hydrocephalus

  • Hirohisa Miyake
  • Patrick Eghwrudjakpor
  • Takashi Sakamoto
  • Masahiro Kurisaka
  • Koreaki Mori

Summary

We measured the content of monoamine neurotransmitters in kaolin-induced hydrocephalic in rat brain. The effects of neurotransmitter changes in hydrocephalic rat brain after injection of a cerebral metabolic activator (bifemelane hydrochloride) are also discussed.

In this study, norepinephrine (NE), dopamine (DA), and serotonin (5-HT) content were determined in several brain regions including the cerebral cortex, striatum, hippocampus, cerebellum, pons, and medulla oblongata.

Bifemelane hydrochloride (bifemelane) was injected intraperitoneally daily for seven days beginning from the seventh day after kaolin injection and measurement was carried out on 15th day during the subacute phase of hydrocephalus.

As a result of the experimental studies, it was recognized that the content of some monoamines following injection of bifemelane was significantly different from the control values in some brain regions. In particular, differences in the cerebral cortex and striatum were significant.

This study demonstrates the effects of injection of a cerebral metabolic activator (bifemelane) on monoamine neurotransmitters in kaolin-induced hydrocephalus in the rat brain.

Keywords

Hydrocephalus Monoamine Neurotransmitter Cerebral metabolic activator Bifemelane hydrochloride 

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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Hirohisa Miyake
  • Patrick Eghwrudjakpor
  • Takashi Sakamoto
  • Masahiro Kurisaka
  • Koreaki Mori
    • 1
  1. 1.Department of NeurosurgeryKochi Medical SchoolKochi, 783Japan

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