Biomechanical Analysis of Hydrocephalus by Different Physical Models
The finite element method (FEM), an advanced numerical method supported by computer technology, was introduced to the biomechanical research on hydrocephalus. In the present study, comparative analysis of intracerebral biomechanics in hydrocephalus was conducted using different physical models.
First, two dimensional finite element analysis with elastic models was performed to clarify the intracerebral stress distribution in hydrocephalus. It showed a characteristic tensile stress concentration at the anterolateral angle of the lateral ventricle. The distribution of stress concentration coincided with the distribution of periventricular lucency on computed tomography (CT) scan. The periventricular tensile stress concentration was decreased by the enlargement of the ventricle. Second, simulation using a hyper-elastic model showed the same pattern of intracerebral stress distribution as the elastic model. However, the former showed wider distribution than the latter. Third, a poroeleastic model was introduced. The poroelastic model is a first approximation of Hakim’s concept of the “open cell sponge”, and it describes cerebrospinal fluid (CSF)/tissue interaction in the hydrocephalic process. The progress of ventricular dilatation and the extension of periventricular cerebrospinal fluid edema were well represented by the poroelastic model.
KeywordsHydrocephalus Computer simulation Cerebrospinal fluid Biomechanics
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