Hydrocephalus pp 237-247 | Cite as

Cerebral Evoked Potentials in Rats with Congenital Hydrocephalus

  • Kozo Mutoh
  • Takehiko Okuno
  • Masatoshi Ito
  • Haruki Mikawa


Cerebral evoked potentials were recorded, in a congenitally hydrocephalic rat strain, HTX, after unilateral forepaw electrical stimulation and monocular flash stimulation. In the hydrocephalic HTX rats, somatosensory evoked potentials (SEPs) were delayed in latency and reduced in amplitude, except for the first cortical positive wave, which was probably subcortical in origin. Therefore, central conduction time was prolonged. The degree of SEP abnormality was inversely correlated with the thickness of the cerebral mantle and SEPs were directly correlated to the pathological severity of hydrocephalus. By contrast, visual evoked potentials (VEPs) in the hydrocephalic group were unaltered when compared with the non-hydrocephalic group, and VEPs were considered less sensitive than SEPs. However, VEPs were abnormal in the four hydrocephalic rats that showed severe behavioral deterioration and were considered to be related to the behavioral alterations.

The HTX strain rats were considered to be appropriate for studying the clinical relevance of cerebral evoked potentials and for further elucidating the mechanism of evoked potential abnormalities in congenital hydrocephalus.


Cerebral evoked potentials Congenital hydrocephalus HTX strain rat Somatosensory evoked potentials Visual evoked potentials 


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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Kozo Mutoh
  • Takehiko Okuno
  • Masatoshi Ito
  • Haruki Mikawa
    • 1
  1. 1.Department of Pediatrics, Faculty of MedicineKyoto UniversityKyoto, 606Japan

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