Advertisement

Hydrocephalus pp 172-180 | Cite as

CSF Absorption Rates in Cats with Kaolin-Induced Hydrocephalus — a Study Using Different Kinds of Tracers of Different Molecular Size

  • Yoshinobu Nakagawa
  • Naomi Fujimoto
  • Keizo Matsumoto

Summary

The absorption rate of CSF was studied in experimental hydrocephalus, using three kinds of tracers. Hydrocephalic cats were divided into three groups: (1) acute, (2) subacute, and (3) chronic. Five normal cats were used as controls. Three different kinds of radioisotope — tritiated water (3H), 14C labeled albumin (14C), and NaH2PO4 (32P) — were used as tracers. Each tracer, dissolved in artificial CSF (MOS-4; SHIMIZU), was perfused between the lateral ventricles in each group. The perfusion pressure was increased stepwise by 5cmH2O and 15cmH2O before ligation of the spinal cord and was increased to 25cmH2O after ligation. In normal cats the absorption rate of tritiated water was almost twice as much as that of 14C and 32P before and after ligation of the spinal cord. Pressure dependency was noted. In acute hydrocephalus the absorption rate for all tracers was reduced to about 1/3 that in normal cats. In the subacute state, the absorption rate of tritiated water (3H) and electrolyte (32P) gradually recovered. In the chronic state, the absorption rate of 14C-labeled albumin also increased before ligation of the spinal cord. After ligation the absorption rate was reduced but was still perceptible. These findings indicated that there may be different pathways for each tracer.

Keywords

Hydrocephalus CSF absorption Blood-brain barrier 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bering EA, Sato O (1963) Hydrocephalus: Changes in formation and absorption of cerebrospinal fluid within the cerebral ventricles. J Neurosurg 20: 1050–1063PubMedCrossRefGoogle Scholar
  2. Eisenberg HM, Mclennar JE, Welch K (1974a) Ventricular perfusion in cats with kaolin-induced hydrocephalus. J Neurosurg 41: 20–28PubMedCrossRefGoogle Scholar
  3. Eisenberg HM, Mclennar JE, Welch K, Treves S (1974b) Radioisotope ventriculograph in cats with kaolin-induced hydrocephalus. Radiology 110: 399–402PubMedGoogle Scholar
  4. Heisey SR, Held D, Pappenheimer JR (1962) Bulk flow and diffusion in the cerebrospinal fluid system of the goat. Am J Physiol 203: 775–781PubMedGoogle Scholar
  5. Hochwald GM, Sahar A, Sadik AR, Ransohoff J (1969) Cerebrospinal fluid production and histological observations in animals with experimental hydrocephalus. Exp Neurol 25: 190–199PubMedCrossRefGoogle Scholar
  6. Hochwald GM, Boal RD, Martin AE, Kuman AJ (1975) Changes in regional bloodflow and water content of brain and spinal cord in acute and chronic experimental hydrocephalus. Rev Med Child Neurol 17: 42–50CrossRefGoogle Scholar
  7. Nakagawa Y, Cervos-Navarro J, Artigas J (1984) A possible paracellular route for resolution of hydrocephalic edema. Acta Neuropathol (Berl) 64: 122–128CrossRefGoogle Scholar
  8. Nakagawa Y, Cervos-Navarro J, Artigas J (1985) Tracer study on a paracellular route in experimental hydrocephalus. Acta Neuropathol (Berl) 65: 247–254CrossRefGoogle Scholar
  9. Nakagawa Y, Fujimoto N, Matsumoto K (1988) Minor CSF pathway in experimental hydrocephalus. Nerv Syst Child 13: 463–468Google Scholar
  10. Ogata J, Hochwald GM, Ransohoff J (1972a) Distribution of intraventricular horseradish peroxidase in normal and hydrocephalic cats. J Neuropathol Exp Neurol 31: 154–163Google Scholar
  11. Ogata J, Hochwald GM, Gravito H, Ransohoff J (1972b) Light and electron microscopic studies of experimental hydrocephalus. Acta Neuropathol (Berl) 21: 213–223CrossRefGoogle Scholar
  12. Sahar A, Hochwald GM, Ransohoff J (1969) Alternate pathway for cerebrospinal fluid absorption in animals with experimental obstructive hydrocephalus. Exp Neurol 25: 200–206PubMedCrossRefGoogle Scholar
  13. Wislocki GB, Putnam TJ (1921) Absorption from the ventricles in experimentally produced internal hydrocephalus. Am J Anat 29: 313–320CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Yoshinobu Nakagawa
    • 1
  • Naomi Fujimoto
  • Keizo Matsumoto
    • 2
  1. 1.Department of NeurosurgeryNational Kagawa Children’s HospitalZentsuji, Kagawa, 765Japan
  2. 2.Department of Neurosurgery, School of MedicineUniversity of TokushimaTokushima, 770Japan

Personalised recommendations