Abstract
Spontaneous hepatitis in the LEC rat is characterized by hyperbilirubinemia, increased levels of serum glutamic-oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in laboratory examination and spotty coagulative necrosis of single hepatocyte without inflammatory cell response [1, 2]. Although a single autosomal recessive gene (hts) has been shown to be responsible for the hepatitis, the mechanism(s) of hepatocyte necrosis in the LEC rat remains obscure. The histological features of the liver reveal a certain resemblance between the hepatitis of LEC rats and the liver necrosis induced by the administration of D-galactosamine (GalN).
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© 1991 Springer-Verlag Tokyo
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Takahashi, H., Enomoto, K., Sakamoto, H., Tobioka, H., Dempo, K., Mori, M. (1991). Sensitivity of LEC Rats to the Hepatotoxic Effects of D-Galactosamine. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_9
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DOI: https://doi.org/10.1007/978-4-431-68153-3_9
Publisher Name: Springer, Tokyo
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