Abstract
(1) Nephrotoxicity of gold: in this case of rheumatoid arthritis, gold deposition was determined as the electron dense filamentous structures in lysosomes of mainly proximal tubules using x-ray energy dispersive analysis. This filamentous structures was a characteristic feature of gold deposition.
25 mg of gold sodium thiomalate was injected into rats in order to clarify the nephrotoxicity of gold. Severe necrosis of pars recta of proximal tubules was induced. Electron dense particles were also observed in the proximal tubules.
(2) Nephrotoxicity of cisplatinum: cisplatinum has well known to be a principal chemotherapeutic agent in the treatment of solid cancer. Chief limit to its greater efficacy, however, is its nephrotoxicity. In this study, the comparison of nephrotoxicity between cisplatinum and transplatinum was investigated.
Cisplatinum induced massive necrosis of pars recta of proximal tubules, whereas transplatinum did not show any morphological change. Urinary enzyme activities (ALP, LAP, y -GTP, NAG, AAP) markedly increased after injection of cisplatinum. Therefore, the daily measurement of urinary enzyme could suggest potential values which indicate not only the degree but also the site of the damaged tubules.
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© 1990 Springer-Verlag Tokyo
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Kaizu, K. (1990). Nephrotoxicities of Gold and Cisplatinum. In: Tomita, H. (eds) Trace Elements in Clinical Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68120-5_33
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DOI: https://doi.org/10.1007/978-4-431-68120-5_33
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68122-9
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