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Osteosarcoma in Children

Preoperative Chemotherapy with Intra-Arterial Cis-Diamminedichloroplatinum-II (CDP) Followed by Tumor Resection, Biological Reconstruction and Postoperative Adjuvant Chemotherapy

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New Developments for Limb Salvage in Musculoskeletal Tumors

Summary

Biological reconstruction of an extremity was performed in seven children undergoing treatment with chemotherapy and tumor resection for osteosarcoma. An allograft was utilized in six patients and an autograft in one. One patient had a local recurrence at 6 months and was treated by hemipelvectomy. Healing at the distal site of the autograft was present prior to the operation. Among the remaining six patients, union occurred in 11 of 12 potential sites of osteosynthesis. Two patients required secondary procedures. All patients have remained free of pulmonary metastases. The patient treated with an autograft developed a secondary (? metastatic) osteosarcoma in the allograft and at other bony sites. Biological reconstruction deserves further investigation as a means of accomplishing limb salvage.

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© 1989 Springer-Verlag Tokyo

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Jaffe, N. et al. (1989). Osteosarcoma in Children. In: Yamamuro, T. (eds) New Developments for Limb Salvage in Musculoskeletal Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68072-7_31

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  • DOI: https://doi.org/10.1007/978-4-431-68072-7_31

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68074-1

  • Online ISBN: 978-4-431-68072-7

  • eBook Packages: Springer Book Archive

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