Summary
Biological reconstruction of an extremity was performed in seven children undergoing treatment with chemotherapy and tumor resection for osteosarcoma. An allograft was utilized in six patients and an autograft in one. One patient had a local recurrence at 6 months and was treated by hemipelvectomy. Healing at the distal site of the autograft was present prior to the operation. Among the remaining six patients, union occurred in 11 of 12 potential sites of osteosynthesis. Two patients required secondary procedures. All patients have remained free of pulmonary metastases. The patient treated with an autograft developed a secondary (? metastatic) osteosarcoma in the allograft and at other bony sites. Biological reconstruction deserves further investigation as a means of accomplishing limb salvage.
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References
Jaffe N, Knapp J, Chuang VP, Wallace S, Ayala A, Murray J, Cangir A, Wang Y-M, Benjamin RS (1983) Osteosarcoma: Intra-arterial treatment of the primary tumor with cis-diamminedichloroplatinum II (CDP). Angiographic, pathologic and pharmacologic studies. Cancer 51: 402–407
Jaffe N, Robertson R, Ayala A, Wallace S, Chuang V, Anzai T, Cangir A, Wang Y-M, Chen T (1985) Comparison of intra-arterial cis-diamminedichloroplatinum-II with high dose methotrexate and citrovorum factor rescue in the treatment of primary osteosarcoma. J Clin Oncol 3: 1101–1104
Jaffe N, Spears R, Eftakhari F, Robertson R, Cangir A, Takaue Y, Raymond K, Wang Y-M (1987) Pathologic fracture in osteosarcoma. Impact of chemotherapy on primary tumor and survival. Cancer 59: 701–709
Jaffe N, Murray J, Ayala A, Wallace S, Raymond K, Carrasco H, Robertson R (1987) Limb salvage using cis-diamminedichloroplatinum-II as preoperative treatment and in the design of post-operative adjuvant treatment in children with osteosarcoma. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, New York, pp 333–341
Sim EH, Ivins JC, Douglas DJ (1978) Surgical treatment of osteogenic sarcoma at the Mayo Clinic. Cancer Treat Rep. 62: 205–211
Burrows HJ, Wilson JN, Scales JT (1975) Excision of tumours of humerus and femur, with restoration by internal prosthesis. J Bone Joint Surg (Br) 57: 148–159
Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 153: 106–120
Pallor RM (1983) Use of biologic fixation in tumor prosthesis development. In: Chao EYS, Ivins JC (eds) Tumor prosthesis for bone and joint reconstruction—The design and application. Thieme-Stratton, New York, pp 429–435
Herrdon CH, Chase JW (1954) The fate of autogenous and homogenous bone grafts including articular surfaces. Surg Gynec Obstet 98: 273–290
Bonfiglio M, Jeter WS, Smith CL (1955) The immune concept: Its relation to bone transplantation. Ann NY Acad 59: 417
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© 1989 Springer-Verlag Tokyo
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Jaffe, N. et al. (1989). Osteosarcoma in Children. In: Yamamuro, T. (eds) New Developments for Limb Salvage in Musculoskeletal Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68072-7_31
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DOI: https://doi.org/10.1007/978-4-431-68072-7_31
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68074-1
Online ISBN: 978-4-431-68072-7
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