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Hemodynamic and Histopathological Consideration of Left Ventricular Assist System on Acute Myocardial Infarction: Experimental and Clinical Investigation

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Recent Progress in Failing Heart Syndrome

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Summary

A left ventricular assist system (LVAS) has been applied to treat the profound heart failure following acute myocardial infarction (AMI). The performance of our original automatic LVAS on AMI was evaluated experimentally and clinically. In chronic animal experiments, the LVAS earned time for the impaired heart to recover while maintaining normal circulation. Decompression of the left ventricle (LV) at the beginning of the LVAS support simultaneously prevented overextension of infarcted myocardium and accelerated scar formation. Gradual increase of LV work promoted the compensation mechanism of residual myocardium. Recovery from profound heart failure after use of the LVAS might have been due to increases in LV end-diastolic volume, left atrial pressure, and heart rate, hypertrophy of residual myocardium, and prevention of dyskinesis by solid scar formation. In clinical cases, the LVAS provided powerful circulatory assistance and maintained near normal circulation, and the heart showed recovery from profound heart failure. Many patients, however, died of multiple organ failure which was probably caused by prolonged ischemia before institution of the LVAS. For completely successful recovery from profound heart failure following AMI, the LVAS should be applied timely before major organs, including the heart, incur irreversible damage.

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Authors and Affiliations

  1. National Cardiovascular Center Research Institute, Suita, Osaka, 565, Japan

    Hisateru Takano & Takeshi Nakatani

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  1. Hisateru Takano
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  2. Takeshi Nakatani
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Editors and Affiliations

  1. The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyama, Japan

    Shigetake Sasayama M.D. (Professor of Medicine) (Professor of Medicine)

  2. Okayama University Medical School, 2-5-1, Shikata-cho, 700, Okayama, Japan

    Hiroyuki Suga M.D., D.M. SC. (Professor of Physiology) (Professor of Physiology)

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© 1991 Springer-Verlag Tokyo

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Takano, H., Nakatani, T. (1991). Hemodynamic and Histopathological Consideration of Left Ventricular Assist System on Acute Myocardial Infarction: Experimental and Clinical Investigation. In: Sasayama, S., Suga, H. (eds) Recent Progress in Failing Heart Syndrome. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67955-4_13

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  • DOI: https://doi.org/10.1007/978-4-431-67955-4_13

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68019-2

  • Online ISBN: 978-4-431-67955-4

  • eBook Packages: Springer Book Archive

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