Neoadjuvant Chemotherapy with FLEP Regimen for Incurable Gastric Cancer

  • Toshifusa Nakajima
  • Keiichiro Ohta
  • Shou Ishihara
  • Shigekazu Ohyama
  • Mitsumasa Nishi
  • Yasuhiko Ohashi
  • Akio Yanagisawa
  • Yo Kato


Although the results of treatment for gastric cancer in Japan have improved, the prognosis of advanced stage disease remains poor [1,2]. Neither chemotherapy nor surgery alone has produced long-term survivors among patients with advanced disease. Our database of gastric cancer cases (11489 cases treated in our hospital from 1946 to 1994) shows that median survival time was 6 months for patients with noncurative surgery and 4 months for nonsurgically treated cases [3]. Our conventional strategy for advanced gastric cancer (including extended radical surgery followed by postoperative chemotherapy) yielded a plateau in the survival benefit. However, recent chemotherapy regimens with high response rates [4, 5, 6, 7, 8, 9] seem to allow radical surgery for initially unresectable disease. Since 1989 at the Cancer Institute Hospital, Tokyo, we have attempted to treat advanced unresectable gastric cancer patients with a four-drug combination chemotherapy with systemic and regional delivery followed by radical gastrectomy. The treatment results have been reported elsewhere [10].


Gastric Cancer Clin Oncol Advanced Gastric Cancer Peritoneal Dissemination Celiac Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 1999

Authors and Affiliations

  • Toshifusa Nakajima
    • 1
  • Keiichiro Ohta
    • 1
  • Shou Ishihara
    • 1
  • Shigekazu Ohyama
    • 1
  • Mitsumasa Nishi
    • 1
  • Yasuhiko Ohashi
    • 2
  • Akio Yanagisawa
    • 3
  • Yo Kato
    • 3
  1. 1.Division of Gastrointestinal SurgeryCancer Institute HospitalTokyoJapan
  2. 2.Division of Medical OncologyCancer Institute HospitalTokyoJapan
  3. 3.Division of PathologyCancer InstituteTokyoJapan

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