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Role of Nitric Oxide in Variations of the Response of Cerebral Blood Flow to Hypotension and Focal Ischemia

  • Conference paper
Ischemic Blood Flow in the Brain

Part of the book series: Keio University Symposia for Life Science and Medicine ((KEIO,volume 6))

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Summary

We contend that there are similarities between the vasoregulatory mechanisms near the lower limit of autoregulation and the region surrounding the ischemic core in focal cerebral ischemia. Cortical nitric oxide synthase (NOS) inhibition raises the lower limit of autoregulation and is thus at least partially responsible for the vasodilation that maintains cerebral blood flow as blood pressure falls from 100 mmHg to 60 mmHg. There are wide variations among animals in the pattern of autoregulation that cannot be explained by damaged vessels or nonphysiological factors. Specific neuronal NOS inhibition does not change the lower limit, suggesting that endothelial NOS mediates the vasodilation near the lower limit. Endothelial NOS immunolocalization in focal ischemia parallels these findings.

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Authors and Affiliations

  1. Department of Anesthesiology, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA, 15212, USA

    Stephen C. Jones & Alexander Kharlamov

  2. Department of Biostatistics, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Yinsheng Qu & Kirk A. Easley

Authors
  1. Stephen C. Jones
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  2. Alexander Kharlamov
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  3. Carol R. Radinsky
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  4. Yinsheng Qu
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  5. Kirk A. Easley
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Editors and Affiliations

  1. Department of Neurology School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Yasuo Fukuuchi M.D. (Professor and Chairman), Minoru Tomita M.D. (Visiting Professor) & Atsuo Koto M.D. (Dean, Keio Junior College of Nursing and Professor) (Professor and Chairman),  (Visiting Professor) &  (Dean, Keio Junior College of Nursing and Professor)

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© 2001 Springer Japan

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Jones, S.C., Kharlamov, A., Radinsky, C.R., Qu, Y., Easley, K.A. (2001). Role of Nitric Oxide in Variations of the Response of Cerebral Blood Flow to Hypotension and Focal Ischemia. In: Fukuuchi, Y., Tomita, M., Koto, A. (eds) Ischemic Blood Flow in the Brain. Keio University Symposia for Life Science and Medicine, vol 6. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67899-1_33

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  • DOI: https://doi.org/10.1007/978-4-431-67899-1_33

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67990-5

  • Online ISBN: 978-4-431-67899-1

  • eBook Packages: Springer Book Archive

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