Summary
We report here the recognition of a new distinctive small group of patients within the spectrum of frontotemporal dementia (FTD) pathology. We present three cases with the clinical diagnosis of frontotemporal dementia (FTD) and neuropathological changes restricted to the medial temporal lobe. The presenting symptoms of these cases were family history of dementia in two of the three cases (two sisters), agitation, apathy, dysphasia, and memory problems. Two of the three cases were clinically diagnosed as Pick’s disease and the third with probable Alzheimer’s disease. Pathologically, they resemble cases reported with hippocampal sclerosis, and ubiquinated inclusions were present in the hippocampus and ventral striatum. Our observations support the existence of a subgroup; we propose to call the cases with distinctive pathology as described in the present paper “Pick D”, as they may be a restricted group who resemble PickC1 according to the division proposed by Constantinidis within Pick’s disease.
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© 2001 Springer Japan
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Ravid, R. et al. (2001). Exclusive Mediotemporal Pathology Within the Spectrum of Frontotemporal Dementia. In: Miyoshi, K., Shapiro, C.M., Gaviria, M., Morita, Y. (eds) Contemporary Neuropsychiatry. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67897-7_26
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DOI: https://doi.org/10.1007/978-4-431-67897-7_26
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-67992-9
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