Summary
Frontotemporal dementia (FTD) is the second most common primary degenerative dementia with early onset and constitutes about 9% of dementia cases examined post mortem. The clinical picture is related to the distribution and severity of the degenerative changes. This chapter analyzes neuropathologically verified cases of Pick’s disease (PiD) and frontal lobe degeneration of non-Alzheimer type (FLD) with regard to heredity and clinical features. When the two groups were compared, there was a female dominance in the PiD group, whereas the FLD group showed a stronger load of heredity concerning similar dementia disorders. A general impression was that symptoms were more prevalent and severe in the PiD group, which is consistent with the more severe atrophy in these cases. In frontotemporal dementia (FTD), as in other dementias, there is a need for a multidimensional classification system, keeping apart etiological, morphological, and clinical aspects. This approach allows flexibility and new combinations that facilitates study and understanding of the nature of FTD.
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Gustafson, L., Passant, U., Gräsbeck, A., Brun, A. (2001). Clinical Variability of Frontotemporal Dementia. In: Miyoshi, K., Shapiro, C.M., Gaviria, M., Morita, Y. (eds) Contemporary Neuropsychiatry. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67897-7_23
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DOI: https://doi.org/10.1007/978-4-431-67897-7_23
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