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Shear stress and the IVUS derived vessel wall thickness

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Vascular Ultrasound

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Summary

The role of shear stress in atherosclerosis has been well documented in vitro. In this chapter a novel technique and several applications will be described. The technique consists of a combination of 3D imaging of blood vessels and Computational Fluid Dynamics. The 3D imaging techniques consist either of 3D-IVUS or a combination of 3D IVUS and Angiography (‘ANGUS’). In the applications of these techniques it will be demonstrated that shear stress pays a role in the prediction of plaque location in in-stent restenosis, in vascular remodeling after balloon angioplasty, and in plaque location in primary atherosclerosis. Attempts to locally increase shear stress by a newly developed flow divider indicate that shear stress accounts for 50% of restenosis.

In conclusion, this chapter describes several new techniques to estimate shear stress and describes the role of this parameter in several conditions, both in humans and in animals in vivo.

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Author information

Authors and Affiliations

  1. Thoraxcenter, The Netherlands

    J. J. Wentzel, P. W. Serruys, C. J. Slager & R. Krams

  2. ICIN, The Netherlands

    J. J. Wentzel & C. Cheng

  3. Cell Biology and Genetics, The Netherlands

    R. de Crom

  4. Vascular Surgery, Erasmus-MC, The Netherlands

    R. de Crom

  5. Ecole Polytechnique, Lausanne, Switzerland

    N. Stergiopulos

Authors
  1. J. J. Wentzel
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  2. C. Cheng
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  3. R. de Crom
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  4. N. Stergiopulos
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  5. P. W. Serruys
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  6. C. J. Slager
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  7. R. Krams
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Editor information

Editors and Affiliations

  1. Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Yoshifumi Saijo M.D., Ph.D.

  2. Thorax Center, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands

    Antonius Franciscus Wilhelmus van der Steen Ph.D.

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© 2003 Springer Japan

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Wentzel, J.J. et al. (2003). Shear stress and the IVUS derived vessel wall thickness. In: Saijo, Y., van der Steen, A.F.W. (eds) Vascular Ultrasound. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67871-7_10

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  • DOI: https://doi.org/10.1007/978-4-431-67871-7_10

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68003-1

  • Online ISBN: 978-4-431-67871-7

  • eBook Packages: Springer Book Archive

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