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Paroxysmal Nocturnal Hemoglobinuria and Related Disorders pp 251–254Cite as

Paroxysmal Nocturnal Hemoglobinuria in Association with Chronic Myelofibrosis

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Abstract

Two cases of chronic idiopathic myelofibrosis (CIMF) associated with paroxixmal nocturnal hemoglobinuria (PNH) are descrived. Case 1 was 60 yrs old male. He was diagnosed CIMF in 1990. Association of PNH was diagnosed in 1995. PNH clone expand gradually, frequent hemolytic episodes were observed. He died by liver failure in 1999. Case 2 was 51 yrs old male. He was daiagnosed as CIMF in 1993 and association of PNH was diagnosed in 2000. Case 2 has no typical hemolytic episode so far. Since both diseases belong to clonal diorder, it is suggested clonal evolution was occurred in CIMF and developed PNH.

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References

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Author information

Authors and Affiliations

  1. Division of Hematology, Internal Medicine, Showa University Fujigaoka Hospital 1-30 Fujigaoka, Aoba-ku, Yokohama, 217-8501, Japan

    Hiroshi Harada, Hiraku Mori, Haruo Niikura & Mitsuhiro Omine

Authors
  1. Hiroshi Harada
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  2. Hiraku Mori
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  3. Haruo Niikura
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  4. Mitsuhiro Omine
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Editor information

Editors and Affiliations

  1. Division of Hematology, Internal Medicine Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, 227-8501, Japan

    Mitsuhiro Omine M.D. (Professor) (Professor)

  2. Department of Immunoregulation, Research Institute for Microbial Diseases Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Taroh Kinoshita Ph.D. (Professor) (Professor)

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© 2003 Springer Japan

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Harada, H., Mori, H., Niikura, H., Omine, M. (2003). Paroxysmal Nocturnal Hemoglobinuria in Association with Chronic Myelofibrosis. In: Omine, M., Kinoshita, T. (eds) Paroxysmal Nocturnal Hemoglobinuria and Related Disorders. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67867-0_26

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  • DOI: https://doi.org/10.1007/978-4-431-67867-0_26

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68004-8

  • Online ISBN: 978-4-431-67867-0

  • eBook Packages: Springer Book Archive

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