Customized Neovascularized Prefabrication in the Rat

  • Yuichi Hirase


Neovascularization is an essential process in natural wound healing, but the precise mechanism of neovascularization is not well understood. On the basis of this unknown consequence of wound healing, the vascular implantation technique can be selected to create customized neovascularized tissue for prefabrication. This concept has been advanced by combination with microsurgical technique to provide customized tissue that specifically meets the size, contour, and tissue type requirements of a given defect.


Skin Flap Free Flap Muscle Flap Myocutaneous Flap Inferior Epigastric Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Erol O.O. (1976) The transplantation of a free skin graft into a vascularized pedicle flap. Plast Reconstr Surg 58:470–477PubMedCrossRefGoogle Scholar
  2. 2.
    Shen T.Y. (1981) Vascular implantation into skin flap: Experimental study and clinical application. A preliminary report. Plast Reconstr Surg 68:404–409Google Scholar
  3. 3.
    Hyakusoku H., Okubo M., Umeda T., Fumiiri M. (1987) A prefabricated hair-bearing island flap for lip reconstruction. Br J Plast Surg 40:37–39PubMedCrossRefGoogle Scholar
  4. 4.
    Shintomi Y., Ohura T. (1982) The use of muscle vascularized pedicle flaps. Plast Reconstr Surg 70:725–734PubMedCrossRefGoogle Scholar
  5. 5.
    Hori Y., Tamai S., Okuda H., Sakamoto H., Takita T., Masuhara K. (1979) Blood vessel transplantation to bone. J Hand Surg 4:23–33Google Scholar
  6. 6.
    Erol O.O., Spira M. (1980) Secondary musculocutaneous flap: An experimental study. Plast Reconstr Surg 65:277–282PubMedCrossRefGoogle Scholar
  7. 7.
    Erk Y., Rose F.A., Spira M. (1983) Vascular augmentation of skin and musculocutaneous flap. Ann Plast Surg 10:341–334PubMedCrossRefGoogle Scholar
  8. 8.
    Erol O.O., Spira M. (1980) Development and utilization of a composite island flap employing omentum: Experimental investigation. Plast Reconstr Surg 65:405–418PubMedCrossRefGoogle Scholar
  9. 9.
    Hirase Y., Valauri F.A., Buncke H.J., Newlin L.Y. (1987) Customized prefabricated neovascularized free flaps. Microsurgery 8:218–224PubMedCrossRefGoogle Scholar
  10. 10.
    Hirase Y., Valauri F.A., Buncke H.J. (1988) Neovascularized bone, muscle, and myo-osseous free flaps: An experimental model. J Reconstr Microsurg 4:209–215PubMedCrossRefGoogle Scholar
  11. 11.
    Hirase Y., Valauri F.A., Buncke H.J. (1988) Neovascularized free cutaneous cartilage flap transfer with microsurgical anastomosis: An experimental model in the rabbit. Ann Plast Surg 21:342–347PubMedCrossRefGoogle Scholar
  12. 12.
    Hirase Y., Valauri F.A., Buncke H.J. (1988) Neovascularized free fat flaps: An experimental model. J Reconstr Microsurg 4:197–201PubMedCrossRefGoogle Scholar
  13. 13.
    Hirase Y., Valauri F.A., Buncke H.J. (1989) Creation of neovascularized free flaps using vein grafts as pedicles: A preliminary report on experimental models. Br J Plast Surg 42:216–222PubMedCrossRefGoogle Scholar
  14. 14.
    Hirase Y., Valauri F.A., Buncke H.J. (1988) Prefabricated sensate myocutaneous and osteomyocutaneous free flaps: An experimental model. Preliminary report. Plast Reconstr Surg 82:440–443PubMedCrossRefGoogle Scholar
  15. 15.
    Valauri F.A., Hirase Y., Buncke H.J. (1988) Prefabricated neovascularized free muscle flaps: pedicle variations. J Reconstr Microsurg 4:203–207PubMedCrossRefGoogle Scholar
  16. 16.
    Duarte A., Valauri F.A., Buncke H.J. (1987) Creating a free muscle flap by neovascularization: An experimental investigation. J Reconstr Microsurg 4:15–18PubMedCrossRefGoogle Scholar
  17. 17.
    Hirase Y., Valauri F.A., Buncke H.J. (1989) An experimental model for ear reconstruction with moulded perichondrial flaps. Br J Plast Surg 42:223–227PubMedCrossRefGoogle Scholar
  18. 18.
    Isogai N., Landis W., Kim T.H., Gerstenfeld L.C., Upton J., Vacanti J.P. (1999) Formation of phalanges and small joints by tissue-engineering. J Bone Joint Surg (Am) 81:306–316PubMedCrossRefGoogle Scholar
  19. 19.
    Khouri R.K., Upton J., Shaw W.W. (1991) Prefabrication of composite free flaps through staged microvascular transfer: An experimental and clinical study. Plast Reconstr Surg 87:108–115PubMedCrossRefGoogle Scholar
  20. 20.
    Homma K., Sugihara H., Ohura T. (1995) Fasciavascularized vs. muscle-vascularized prefabricated flaps using tissue expanders: An experimental study in a rat model. J Reconstr Microsurg 11:221–229PubMedCrossRefGoogle Scholar
  21. 21.
    Khouri R.K., Ozbek M.R., Hruza G.J., Young V.L. (1995) Facial reconstruction with prefabricated induced expanded (PIE) suprac1avicular skin flaps. Plast Reconstr Surg 95:1007–1017PubMedCrossRefGoogle Scholar
  22. 22.
    Hirase Y., Kojima T., Takeishi M., Kwang K.H., Tanaka M. (1993) Transplantation of long-term cryo preserved allocutaneous tissue by skin graft or microsurgical anastomosis. Plast Reconstr Surg 91:492–501PubMedCrossRefGoogle Scholar
  23. 23.
    Hirase Y., Kojima T., Takeishi M., Matsui M., Terao Y. (1996) Long-term cryo preserved allogeneic nervous and vascular tissue transfer in monkeys. J Microsurg 17:301–305CrossRefGoogle Scholar
  24. 24.
    Hirai T., Manders E.K., Hughes K., Oki K., Hyakusoku H. (1996) Experimental study of allogeneically vascularized prefabricated flaps. Ann Plast Surg 37:394–399PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2003

Authors and Affiliations

  • Yuichi Hirase

There are no affiliations available

Personalised recommendations