Skin and Muscle Flaps in the Rat

  • Yuichi Hirase


With advances in microsurgical techniques and materials, it has been possible to investigate free transfer of living tissue in great detail. Successful transfer has been demonstrated in animals, especially in rats. Rats are in expensive and easy to keep in the laboratory, and their anatomy and immunogenesis are relatively well understood. Therefore, the rat is the most suitable animal for experiments on microsurgery in the laboratory. Some kinds of skin and muscle flaps have been especially selected for experiments to develop microsurgical techniques and investigate the effect of drugs.


Free Flap Muscle Flap Latissimus Dorsi Muscle Femoral Vessel Free Tissue Transfer 
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  1. 1.
    Ruby L.K., Greene M., Risitano G., Torrejon R., Belsky M.R. (1984) Experience with epigastric free flap transfer in the rat: Technique and results. Microsurgery 5:102–104PubMedCrossRefGoogle Scholar
  2. 2.
    De-La-Pena J.A., Lineweaver W., Buncke H.J. (1988) Microvascular transfers of latissimus dorsi and serratus anterior muscles in rats. Microsurgery 9:18–20PubMedCrossRefGoogle Scholar
  3. 3.
    Shapiro R.I., Cerra F.B. (1978) A model for reimplantation and transplantation of a complex organ: The rat hind limb. J Surg Res 24:501–506PubMedCrossRefGoogle Scholar
  4. 4.
    Strauch B., Murray D.E. (1967) Transfer of composite grafts with immediate suture anastomosis of its vascular pedicle measuring less than 1 mm in external diameter using microsurgical techniques. J Plast Reconstr Surg 40:325–329CrossRefGoogle Scholar
  5. 5.
    Acland R.D. (1980) Microsurgical practice manual. C.V. Mosby, St. LouisGoogle Scholar
  6. 6.
    Parsa F.D., Spira M. (1979) Evaluation of anastomotic techniques in the experimental transfer of free skin flaps. Plast Reconstr Surg 63:696–699PubMedCrossRefGoogle Scholar
  7. 7.
    Raskin D.J., Erk Y., Spira M., Melissinos E.G. (1983) Tissue pH monitoring in microsurgery: A preliminary evaluation of continuous tissue pH monitoring as an indicator of perfusion disturbances in microvascular free flaps. Ann Plast Surg 11:331–339PubMedCrossRefGoogle Scholar
  8. 8.
    Dickson M.G., Sharpe D.T. (1985) Continuous subcutaneous tissue pH measurement as a monitor of blood flow in skin flaps: an experimental study Br J Plast Surg 38:39–42PubMedCrossRefGoogle Scholar
  9. 9.
    Hirase Y., Cho S.H., Park B.K., Kojima T. (1991) Tissue pH monitoring in microsurgery: Experimental model of muscle, cutaneous flap in rats (in Japanese). J Jpn Soc Microsurg 4:145–150Google Scholar
  10. 10.
    Harashina T., Sawada Y., Watanabe S. (1977) The relationship between venous occlusion time in island flaps and flap survivals. Plast Reconstr Surg 60:92–95PubMedCrossRefGoogle Scholar
  11. 11.
    Nakajima T. (1978) How soon do venous drainage channels develop at the periphery of a free flap? A study in rats. Br J Plast Surg 31:300–308PubMedGoogle Scholar
  12. 12.
    McKee N.H., Clarke H.M., Manktelow R.T. (1981) Survival following vascular compromise in an island skin flap. Plast Reconstr Surg 67:200–204PubMedGoogle Scholar
  13. 13.
    Su C-T., Im M.J., Hoops J.E. (1982) Tissue glucose and lactate following vascular occlusion in island skin flaps. Plast Reconstr Surg 70:202–205PubMedCrossRefGoogle Scholar
  14. 14.
    Ballantyne D.L., Reid C.A., Harper A.D., Shaw W.W. (1980) The effects of short-term preservation on microvascular free groin flaps in rats. J Microsurg 2:101–105PubMedCrossRefGoogle Scholar
  15. 15.
    Doi K. (1979) Homotransplantation of limbs in rats. Plast Reconstr Surg 64:613–621PubMedGoogle Scholar
  16. 16.
    Lipson R.A., Kawano H., Halloran P.F., McKee N.H., Pritzker K.P.H., Langer F. (1983) Vascularized limb transplantation in the rat. Transplantation 35:293–299PubMedCrossRefGoogle Scholar
  17. 17.
    Yamaguchi T., Hamada Y., Akamatsu N., Sato H. (1987) Experimental study concerning allograft of vascularized composite tissue (second report) (in Japanese). Jpn J Transpl 22:463–468Google Scholar
  18. 18.
    Yamaguchi Y., Akamatsu N., Hamada Y., Sato H., Toshima T., Hagino T. (1989) Experimental study on vascularized fresh whole joint allograft transplantation (in Japanese). J Jpn Orthop Assoc 63:296–307Google Scholar
  19. 19.
    Yamaoka N., Tamai S., Mizumoto S. (1997) Experimental study of vascularized bone grafts in rat: Effect of mechanical loading on bone dynamics. J Orthop Sci 2:239–247CrossRefGoogle Scholar
  20. 20.
    Black K.S., Hewitt C.W., Woodard T.L., Adrig L.M., Litke D.K., Howard E.B., Achauner B.M., Martin D.C., Furnas W. (1982) Efforts to enhance survival of limb allografts by prior administration of whole blood in rats using a new survival end-point. J Microsurg 3:162–167PubMedCrossRefGoogle Scholar
  21. 21.
    Tsucbida Y., Usui M., Naitoh T., Takahashi T., Murakami M., Ueda T. (1997) Limb allografts in rats treated with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies. J Reconstr Microsurg 13:107–110CrossRefGoogle Scholar
  22. 22.
    Hirase Y., Kojima T., Uchida M. (1992) Cryopreserved allogeneic vessels and nerve graft: Hind limb replantation model in the rat. J Reconstr Microsurg 8:437–443PubMedCrossRefGoogle Scholar
  23. 23.
    Chiu D.T.W., Chen L., Chen Z-W. (1990) Rat ear reattachment as an animal model. Plast Reconstr Surg 85:782–788PubMedCrossRefGoogle Scholar

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© Springer Japan 2003

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  • Yuichi Hirase

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