Abstract
When a vascularized fibula graft was performed for a bone defect in the extremity long bones, significant hypertrophy was observed when the graft was transferred to a mechanically loaded lower extremity, but less hypertrophy was observed when it was transfered to the upper extremities. This phenomenon of hypertrophy is related to the imposed mechanical stress load [1–3]. We designed a murine experiment to clarify the etiology of postoperative hypertrophy of vascularized bone grafts. We performed syngeneic vascularized ulna transfer to a segmental bone defect in the rat, with or without mechanical loading. The bone dynamics of the grafts were examined by fluarochrome bone labeling and histomorphological measurement.
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References
DeBoer H.H., Wood M.B. (1989) Bone changes in the vascularized fibular graft. J Bone Joint Surg Br 71B:374–378
Malizos K.N., Nunley J.A., Goldner R.D., et al. (1993) Free vascularized fibula in traumatic long bone defects and in limb salvaging following tumor resection: comparative study. Microsurgery 14:368–374
Yajima H., Tamai S. (1994) Twin-barreled vascularized fibular grafting to the pelvis and lower extremity. Clin Orthop 303:178–184
Goshima J. (1986) The effect of ischemia on bone tissue: bone histomorphometrical analysis. J Nara Med Assoc(Nara Igakukaisi) 37:325–357 (in Japanese)
Inoue J., Takahashi H. (1983) Processing of undecalcified bone specimens and histomorphometric analysis of bone. Orthop Surg Traumatol(Seikeisaigaigeka) 26:1251–1260 (in Japanese)
Takahashi M., Yabe Y., Yoshizawa E., Suzuki T. (1979) Congenital pseudoarthrosis of the tibia treated by the vascularized free fibula graft. Orthop Surg Traumatol(Seikeisaigaigeka) 22:1405–1411 (in Japanese)
Tamai S., Sakamoto H., Fukui A., et al. (1983) Vascularized fibula graft for the treatment of congenital pseudarthrosis of long bone. Orthop Surg Traumatol(Seikeisaigaigeka) 26:601–612 (in Japanese)
Taylor G.I., Buncke H.J., Watson N., et al. (1979) Vascularized osseous transplantation for reconstruction of the tibia. In: Serrafin D., Buncke H.J., eds. Microsurgical composite tissue transplantation. Mosby, St. Louis, pp 713–742
Weiland A.J., Phillips T.W., Randolph M.A. (1984) Bone grafts: a radiologic, histologic, and biomechanical model comparing autografts, allografts, and free vascularized bone grafts. Plast Reconstr Surg 74:368–379
Wolff J. (1892) Das Gesets der Transformation der Knochen. Verlag von August Hirschward, Berlin
Chamey A., Tschants P. (1972) Mechanical infiuences in bone remodeling. Experimental research on Wolffs law. J Biomech 5:173–180
Goodship A.E., Lanyon L.E., McFie H. (1979) Functional adaptation of bone to increased stress. J Bone Joint Surg Am 61A:539–546
Urthoff H.K., Jaiworski Z.F.G. (1978) Bone loss in response to long-term immobilization. J Bone Joint Surg Br 60B:420–429
Aro H., Eerola E., Aho A. (1985) Development of non unions in the rat fibula after removal of periosteal neural mechanoreceptors. Clin Orthop 199:292–299
Mizumoto S. (1987) Experimental study on vascularized bone graft in rats: with special emphasis on the hypertrophy of grafted bone. J Nara Med Assoc(Nara Igakukaisi) 38:667–706 (in Japanese)
Enneking W.F., Mindell E.R. (1991) Observations on massive retrieved human allografts. J Bone Joint Surg Am 73A:1123–1142
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© 2003 Springer Japan
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Yamaoka, N., Tamai, S., Mizumoto, S. (2003). Vascularized Ulna Graft in the Rat. In: Tamai, S., Usui, M., Yoshizu, T. (eds) Experimental and Clinical Reconstructive Microsurgery. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67865-6_11
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DOI: https://doi.org/10.1007/978-4-431-67865-6_11
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-67998-1
Online ISBN: 978-4-431-67865-6
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