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Remodeling: How Vessels Narrow

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Cardiac-Vascular Remodeling and Functional Interaction

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Abstract

Vascular narrowing is the fundamental defect characterizing atherosclerosis and hypertension. This loss of physiological caliber occurs despite the remarkable ability of normal vessels to maintain the caliber appropriate for the blood flow needed for the subservient organ. Indeed, the ability to adjust caliber must be very primitive. The vessel tree, like any closed circuit, can only continue to conduct blood if each branch has an appropriate resistance to flow. Flow, moreover, is proportional to the fourth power of the radius. Thus, the normal vessel wall must and does have an exquisite mechanism for controlling lumen size.

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Authors and Affiliations

  1. Department of Pathology, University of Washington, Seattle, 98195-7335, WA, USA

    Stephen M. Schwartz

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  1. Stephen M. Schwartz
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Editors and Affiliations

  1. First Department of Internal Medicine, Fukushima Medical College, Hikariga-oka 1, 960-12, Fukushima, Japan

    Yukio Maruyama M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565, Japan

    Masatsugu Hori M.D., Ph.D. (Chief) (Chief)

  3. College of Veterinary Medicine, Auburn University, 106 Greene Hall, 36849-5517, Auburn, AL, USA

    Joseph S. Janicki Ph.D. (Professor, Associate Dean of Research and Graduate Studies) (Professor, Associate Dean of Research and Graduate Studies)

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© 1997 Springer Japan

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Schwartz, S.M. (1997). Remodeling: How Vessels Narrow. In: Maruyama, Y., Hori, M., Janicki, J.S. (eds) Cardiac-Vascular Remodeling and Functional Interaction. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67041-4_7

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  • DOI: https://doi.org/10.1007/978-4-431-67041-4_7

  • Publisher Name: Springer, Tokyo

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