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Effects of Flavonoids on Cell Cycle and Differentiation in Cancer Cells

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Food Factors for Cancer Prevention

Summary

Flavonoids are plant pigments found in edible fruits and vegetables. We examined the effects of Flavonoids on cell cycle progression and differentiation of malignant tumor cells. Flow cytometric analysis showed that flavone, luteolin, quercetin, and daidzein induced G1 arrest, whereas genistein specifically inhibited the cell cycle at G2-M in the human gastric cancer cell line HGC-27. Other flavonoid, apigenin, also arrested the cell cycle of B104 rat neuronal cells at G2-M phase. Inhibition of the cell cycle at two major checkpoints, G 1 and G2-M, may be important to the antitumor activities of the flavonoids. Furthermore, apigenin induced morphological differentiation of B104 cells, which suggests an unknown pathway of differentiation from G2-M.

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Author information

Authors and Affiliations

  1. Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto 602, Japan

    Yoshizumi Matsukawa, Fumiko Sato & Toshiyuki Sakai

  2. Hyogo Institute for Oriental Medicine, Daimotsu-cho, Amagasaki, Hyogo 660, Japan

    Fumiko Sato

Authors
  1. Yoshizumi Matsukawa
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  2. Fumiko Sato
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  3. Toshiyuki Sakai
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Editor information

Editors and Affiliations

  1. Department of Food Science and Technology Faculty of Agriculture, Kyoto University, Oiwake-cho, Kitashirakawa, Kakyo-ku, Kyoto, 606-01, Japan

    Hajime Ohigashi Ph.D. (Professor) (Professor)

  2. Department of Applied Biological Sciences Faculty of Agriculture, Nagoya University, Furocho, Chikusa-ku, Nagoya, Aichi, 464-01, Japan

    Toshihiko Osawa Ph.D. (Professor) (Professor)

  3. Lipid Science Laboratory, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305, Japan

    Junji Terao Ph.D. (Head) (Head)

  4. Nutrition and Epidemiology, Department of Agriculture, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156, Japan

    Shaw Watanabe M.D. (Professor) (Professor)

  5. First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602, Japan

    Toshikazu Yoshikawa M.D. (Associate Professor) (Associate Professor)

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© 1997 Springer Japan

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Matsukawa, Y., Sato, F., Sakai, T. (1997). Effects of Flavonoids on Cell Cycle and Differentiation in Cancer Cells. In: Ohigashi, H., Osawa, T., Terao, J., Watanabe, S., Yoshikawa, T. (eds) Food Factors for Cancer Prevention. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67017-9_123

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  • DOI: https://doi.org/10.1007/978-4-431-67017-9_123

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67019-3

  • Online ISBN: 978-4-431-67017-9

  • eBook Packages: Springer Book Archive

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