Abstract
The electrophysiological effects of KST-5452, an ml muscarinic acetylcholine receptor (AChR) binding compound (Kishida et al. 1994), and linopirdine, a neurotransmitter release enhancer (Aiken et al. 1996; Nickolson et al. 1990) were studied in NG108-15 neuroblastoma x glioma hybrid cells transfected with ml-muscarinic AChR cDNA, using either the conventional whole-cell or the nystatin perforated-patch recording mode under voltage-clamp conditions.
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Aiken SP, Zaczek R, and Brown BS (1996) Pharmacology of the neurotransmitter release enhancer linopirdine (DuP 996), and insights into its mechanism of action. Adv Pharmacol 35:349–384
Kishida H, Yamamoto K, Fuse Y, et al (1994) Activation of inward current associated with M-potassium current inhibition in ml-muscarinic receptor-transformed NG108–15 cells by KST-5452, a novel cognition enhancer. Neurosci Lett 172:119–121
Lamas JA, Selyanko AA, Brown DA (1997) Effects of a cognition-enhancer, linopirdine (DuP 996), on M-type potassium currents I(K(M)) and some other voltage- and ligandgated membrane currents in rat sympathetic neurons. Eur J Neurosci 9:605–616
Nickolson VJ, Tarn SW, Meyers MJ, et al (1990) DuP 996 (3, 3-bis(4-pyridinylmethyl)-l-phenylindolin-2-one) enhances the stimulus-induced release of acetylcholine from rat brain in vitro and in vivo. Drug Dev Res 19:285–300
Noda M, Obana M, Akaike N (1998) Inhibition of M-type K+ current by linopirdine, a neurotransmitter release enhancer, in NG108–15 neuronal cells and rat cerebral neurons in culture. Brain Res 794:274–280
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© 2000 Springer Japan
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Noda, M., Higashida, H., Akaike, N. (2000). Inhibition of M-Type K+ currents by Cognition Enhancers in NG108-15 Cells and Rat Cerebral Neurons in Culture. In: Kuba, K., Higashida, H., Brown, D.A., Yoshioka, T. (eds) Slow Synaptic Responses and Modulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66973-9_6
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DOI: https://doi.org/10.1007/978-4-431-66973-9_6
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-66975-3
Online ISBN: 978-4-431-66973-9
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