Abstract
The slow synaptic response in the spinal dorsal horn (DH) was originally found by Urban and Randic (1984). Tetanic stimulation of high-threshold primary afferent fibers in the dorsal root (DR) was found to induce a slow depolarization associated with spike and excitatory postsynaptic potential (epsp) discharges in the DH neurons in a slice preparation. Bath application of substance P, the putative pain transmitter/modulator, was shown to mimic the slow synaptic response. Since then, evidence has accumulated that the slow synaptic response lasting for more than 1 mm might take a critical role in nociceptive information transmission (Randic et al.1987; Urban et al.1994; Yoshimura 1996). However, some of the important characteristics including the precise site of cells generating slow synaptic responses and the induction mechanisms are still unclear primarily due to the methodological limitations of intracellular recording techniques.
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References
Andrew RD, MacVicar BA (1994) Imaging cell volume changes and neuronal excitation in the hippocampal slice. Neurosci 62:371–383
Bear MF, Abraham WC (1996) Long-term depression in hippocampus. Annu Rev Neurosci 19:437–462
Federico P, Borg SG, SalkausKus AG, et al (1994) Mapping patterens of neuronal activity and seizure propagation by imaging intrinsic optical signals in the isolated whole brain of the guinea-pig. Neurosci 58:461–480
Grinvald A, Frosting RD, Lieke E, et al (1988) Optical imaging of neuronal activity. Physiol Rev 68:1285–1365
Grinvald A, Lieke E, Frostig RD, et al (1986) Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature (Lond) 324:361–364
Haglund MM, Ojemann GA, Hochman DW (1992) Optical imaging of epileptiform and functional activity in human cerebral cortex. Nature (Lond) 358:668–671
Holthoff K, Witte OW (1996) Intrinsic optical signals in rat neocortical slices measured with near-infrared dark-field microscopy reveal changes in extracellular space. J Neurosci 16:2740–2749
Hopp HP, Wu JY, Falk CX, et al (1990) Multisite optical measurement of membrane potential. In: Boulton AA, Vanderwolf CH (eds) Neurophysiological techniques: basic methods and concepts, Humana Press, Clinton NJ, pp193–226
Ikeda H, Ryu PD, Park JB, et al (1998) Optical responses evoked by single-pulse stimulation to the dorsal root in the rat spinal dorsal horn in slice. Brain Res 812:81–90
Kita H, Yamada H, Tanifuji M, et al(1995) Optical responses recorded after local stimulation in rat neostriatal slice preparations: effects of GABA and glutamate antagonists, and dopamine agonists. Exp Brain Res 106:187–195
Lipton P (1973) Effects of membrane depolarization on light scattering by cerebral cortical slices. J Physiol (Lond) 231:365–383
Malzack R, Wall PD (1965) Pain mechanisms: a new theory. Science 150:971–979.
Murase KM (1983) Electrophysiological properties of rat spinal dorsal horn neurones in vitro. J Physiol (Lond) 334:141–153
Murase K, Saka T, Terao S, et al (1997) Slow optical response in rat spinal dorsal horn in slice. Soc Neurosci Abstr 27:1081
Murase K, Sakata T, Terao S, et al (1998) Slow intrinsic optical signals in the rat spinal dorsal horn in slice. Neuroreport 9: 3663–3667.
Randic M (1986) Plasticity of excitatory synaptic transmission in the spinal cord dorsal horn. Prop Brain Res 113:463–506
Randic M, Murase K, Ryu PD, et al (1987) Slow excitatory transmission in the rat spinal dorsal horn: possible mediation by tachykinins. Biomed Res 8 (suppl):71–82
Sandkiihler J, Chen JG, Cheng G, et al (1997) Low-frequency stimulation of afferent Aδfibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat. J Neurosci 17:6483–6491
Svoboda J, Sykova E (1991) Extracellular space volume changes in the rat spinal cord produced by nerve stimulation and peripheral injury. Brain Res 560:216–224
Tanifuji M, Sugiyama T, Murase K (1994) Horizontal propagation of excitation in rat visual cortical slices revealed by optical imaging. Science 266:1057–1059
Urban L, Randic M (1984) Slow excitatory transmission in rat dorsal horn: possible mediation by peptides. Brain Res 290:336–341
Urban L, Thompson SWN, Dray A (1994) Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters. Trends Neurosci 17:432–438
Yoshimura M (1996) Slow synaptic transmission in the spinal dorsal horn. Prog Brain Res 113:443–462
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© 2000 Springer Japan
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Murase, K., Ikeda, H., Terao, S., Asai, T. (2000). Slow Intrinsic Optical Signals in Rat Spinal Cord Slices and Their Modulation by Low-Frequency Stimulation. In: Kuba, K., Higashida, H., Brown, D.A., Yoshioka, T. (eds) Slow Synaptic Responses and Modulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66973-9_59
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DOI: https://doi.org/10.1007/978-4-431-66973-9_59
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