Abstract
Neuronal functions, including synaptic responses, are highly coordinated by a variety of molecules expressed in neurons. However, it remains obscure how this coordination is maintained. It is still unknown how genes essential for neuronal activity are regulated at the transcriptional level. Our group is working on the regulation of expression of the NMDA receptor subunit type 1 (NR1) gene during neuronal differentiation. NR1 is an essential subunit of functional NMDA receptors (Sucher et al. 1996). The expression of the NR1 gene is induced as neuronal differentiation proceeds (Monyer et al. 1994; Laurie and Seeburg 1994). NR1 is expressed in virtually every neuron throughout the central nervous system (Morisaki et al. 1991) Thus, NR1 is a good model for the exploration of gene regulation in neurons.
Key words
- NMDA receptor
- Gene regulation
- Neuron
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© 2000 Springer Japan
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Okamoto, SI., Sherman, K., Lipton, S.A. (2000). How Are Neuronal Genes Expressed in Neurons? Regulation of NMDA Receptor Subunit Type 1 Gene as a Model. In: Kuba, K., Higashida, H., Brown, D.A., Yoshioka, T. (eds) Slow Synaptic Responses and Modulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66973-9_47
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DOI: https://doi.org/10.1007/978-4-431-66973-9_47
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-66975-3
Online ISBN: 978-4-431-66973-9
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