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Introductory Review: Exocytosis and Modulation

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Book cover Slow Synaptic Responses and Modulation

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Summary

A nerve impulse arrived at the nerve terminal activates voltage-gated Ca2+ channels and causes rapid Ca2+ influx. The high Ca2+ concentration produced in an active zone of the presynaptic terminal triggers the fusion of docked synaptic vesicles via low-affinity Ca2+-binding proteins and thus elicits neurotransmitter release. Synaptic vesicles are locally replenished by endocytosis. A fairly number of proteins and their interactions are involved in neurotransmitter exocytosis and synaptic vesicle recycling. Most of these processes are regulated by neuromodulators.

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Authors and Affiliations

  1. Department of Physiology, Tokyo Medical University, 1-1 Shinjuku-6-chome, Shinjuku-ku, Tokyo, 160-8402, Japan

    S. Mochida

  2. Department of Physiology, School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    K. Kuba

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  1. S. Mochida
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  2. K. Kuba
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Editors and Affiliations

  1. Department of Physiology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8850, Japan

    Kenji Kuba M.D., D.M.Sc. (Professor) (Professor)

  2. Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan

    Haruhiro Higashida M.D., D.M.Sc. (Professor) (Professor)

  3. Department of Pharmacology, University College London, Gower Street, London, WCIE 6BT, England, UK

    David A. Brown Ph.D. (F.R.S. Professor) (F.R.S. Professor)

  4. Department of Molecular Neurobiology, School of Human Science, Waseda University, Tokorozawa, Saitama, 359-1192, Japan

    Tohru Yoshioka Ph.D. (Professor) (Professor)

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Mochida, S., Kuba, K. (2000). Introductory Review: Exocytosis and Modulation. In: Kuba, K., Higashida, H., Brown, D.A., Yoshioka, T. (eds) Slow Synaptic Responses and Modulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66973-9_29

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  • DOI: https://doi.org/10.1007/978-4-431-66973-9_29

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