Abstract
The presence of macrophages within tumor tissue is one of the histological characteristics of malignant gliomas. Although the infiltration of macrophages suggests a possible immunological reaction by the host, the mechanisms and biological meaning of macrophage infiltration in malignant gliomas remain to be defined. A human monocyte chemoattractant protein-1 (MCP-1) was purified from the culture fluid of human glioma cell lines. MCP-1 is a 76-amino acid protein. MCP-1 is chemotactic for monocytes, but not for macrophages with an immunophenotype of the tissue-fixed, resident type. Expression and production of MCP-1 in glioma tissues and meningioma tissues were found, and there was a positive correlation between the degree of macrophage infiltration and the level of MCP-1 expression by tumor cells. Transplantation of tumor cells transfected by MCP-1 cDNA exhibited a lower growth rate than parental cells. Therefore, we speculate that tumor-associated macrophages have a suppressive effect on the growth of tumors. For clinical application of MCP-1, we measured MCP-1 concentration in cerebrospinal fluid (CSF) by enzyme-linked immunosorbent assay (ELISA). High concentration of MCP-1 was found in the CSF from malignant glioma patients with subarachnoid dissemination. Thus, measuring MCP-1 concentration in CSF may lead us to more accurate diagnosis of malignant glioma and detection of subarachnoid dissemination of the tumor cells. Further study on MCP-1 is warranted for its possible clinical applications.
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Kuratsu, Ji. et al. (1996). Monocyte Chemoattractant Protein-1 (MCP-1) Derived from Brain Tumors: Its Significance and Clinical Application. In: Nagai, M. (eds) Brain Tumor. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66887-9_32
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DOI: https://doi.org/10.1007/978-4-431-66887-9_32
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-66889-3
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