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Monocyte Chemoattractant Protein-1 (MCP-1) Derived from Brain Tumors: Its Significance and Clinical Application

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Book cover Brain Tumor

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Abstract

The presence of macrophages within tumor tissue is one of the histological characteristics of malignant gliomas. Although the infiltration of macrophages suggests a possible immunological reaction by the host, the mechanisms and biological meaning of macrophage infiltration in malignant gliomas remain to be defined. A human monocyte chemoattractant protein-1 (MCP-1) was purified from the culture fluid of human glioma cell lines. MCP-1 is a 76-amino acid protein. MCP-1 is chemotactic for monocytes, but not for macrophages with an immunophenotype of the tissue-fixed, resident type. Expression and production of MCP-1 in glioma tissues and meningioma tissues were found, and there was a positive correlation between the degree of macrophage infiltration and the level of MCP-1 expression by tumor cells. Transplantation of tumor cells transfected by MCP-1 cDNA exhibited a lower growth rate than parental cells. Therefore, we speculate that tumor-associated macrophages have a suppressive effect on the growth of tumors. For clinical application of MCP-1, we measured MCP-1 concentration in cerebrospinal fluid (CSF) by enzyme-linked immunosorbent assay (ELISA). High concentration of MCP-1 was found in the CSF from malignant glioma patients with subarachnoid dissemination. Thus, measuring MCP-1 concentration in CSF may lead us to more accurate diagnosis of malignant glioma and detection of subarachnoid dissemination of the tumor cells. Further study on MCP-1 is warranted for its possible clinical applications.

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Authors and Affiliations

  1. Department of Neurosurgery, Kumamoto University Medical School, Kumamoto 860, Japan

    Jun-ichi Kuratsu, Hideo Takeshima, Toru Nishi, Kyoichi Sato, Kimio Yoshizato, Shigeo Yamashiro & Yukitaka Ushio

  2. Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick, MD, USA

    Teizo Yoshimura

Authors
  1. Jun-ichi Kuratsu
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  2. Hideo Takeshima
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  3. Toru Nishi
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  4. Kyoichi Sato
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  5. Kimio Yoshizato
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  6. Shigeo Yamashiro
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  7. Yukitaka Ushio
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  8. Teizo Yoshimura
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Editors and Affiliations

  1. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, 321-02, Japan

    Masakatsu Nagai M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

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© 1996 Springer Japan

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Kuratsu, Ji. et al. (1996). Monocyte Chemoattractant Protein-1 (MCP-1) Derived from Brain Tumors: Its Significance and Clinical Application. In: Nagai, M. (eds) Brain Tumor. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66887-9_32

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  • DOI: https://doi.org/10.1007/978-4-431-66887-9_32

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-66889-3

  • Online ISBN: 978-4-431-66887-9

  • eBook Packages: Springer Book Archive

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