Electrochemical carboxylation of various vinyl bromides under an atmospheric pressure of carbon dioxide with a Pt cathode and an Mg anode gave the corresponding α,ß-unsaturated carboxylic acids in high yields. In the case of alkyl-substituted vinyl bromides, efficient electrochemical carboxylation was achieved by the addition of 20 mol% of NiBr2•bpy. These facile carboxylations were successfully applied to a synthesis of the precursors of nonsteroidal anti-inflammatory agents.
- Unsaturated Acid
- Aryl Bromide
- Platinum Cathode
- Unsaturated Carboxylic Acid
- Magnesium Anode
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Tokuda, M., Kamekawa, H., Senboku, H. (1998). Synthesis of α,β-Unsaturated Carboxylic Acids by Electrochemical Carboxylation of Vinyl Bromides and Its Application to the Synthesis of Anti-Inflammatory Agents. In: Torii, S. (eds) Novel Trends in Electroorganic Synthesis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65924-2_72
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