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Notes on the Disease Mechanism and Genetics of Rheumatoid Arthritis

  • Conference paper
Mechanical Loading of Bones and Joints

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Summary

Rheumatoid arthritis (RA) is a chronic polyarthritis of unknown etiology that affects about 1% of the population worldwide. The risk of the disease in the siblings of affected individuals (λ s ) is significantly increased in RA, suggesting that both genetic and environment factors are important in the pathogenesis of RA. Previous studies in this laboratory have shown that features characteristic to RA, synovial overgrowth and bone resorption, can be experimentally reproduced by augmenting the expression of the c-fos protooncogene. We have searched the human genome for genes that predispose to RA using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marker loci. Three principal chromosome regions of linkage, D1S253/214, D8S556 and DXS1232, have been identified which we call RAI, RA2 and RA3 for rheumatoid arthritis disease loci.

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Author information

Authors and Affiliations

  1. Kobe University School of Medicine Faculty of Health Science, 7-10-2 Tomogaoka, Sumaku, Kobe 654, Japan

    Shunichi Shiozawa, Hiroki Kawasaki, Yasuo Tsukamoto, Sachiko Hayashi, Koichiro Komai, Naoko Mukae, Eri Yamamoto & Norishige Yoshikawa

  2. Center for Rheumatic Diseases, Kakogawa National Hospital, 1545-1 Saijo, Kakogawa 675, Japan

    Yoshitake Konishi & Kazuko Shiozawa

Authors
  1. Shunichi Shiozawa
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  2. Hiroki Kawasaki
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  3. Yasuo Tsukamoto
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  4. Sachiko Hayashi
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  5. Yoshitake Konishi
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  6. Koichiro Komai
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  7. Naoko Mukae
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  8. Eri Yamamoto
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  9. Norishige Yoshikawa
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  10. Kazuko Shiozawa
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Editor information

Editors and Affiliations

  1. Department of Orthopedic Surgery, Niigata University School of Medicine, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan

    Hideaki E. Takahashi M.D., Ph.D. (Professor and Chair) (Professor and Chair)

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© 1999 Springer-Verlag Tokyo

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Shiozawa, S. et al. (1999). Notes on the Disease Mechanism and Genetics of Rheumatoid Arthritis. In: Takahashi, H.E. (eds) Mechanical Loading of Bones and Joints. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65892-4_20

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  • DOI: https://doi.org/10.1007/978-4-431-65892-4_20

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65894-8

  • Online ISBN: 978-4-431-65892-4

  • eBook Packages: Springer Book Archive

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