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Hydrolytic Degradation of Poly(L-Lactide-co-ε-Caprolactone)S

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Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

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Summary

Poly(ε-caprolactone-co L-lactide)s were synthesized at various feed ratios by ring-opening polymerization using tin(II) octanoate as an initiator. The biodegradability of these copolymers was evaluated with both enzymatic and non-enzymatic hydrolyses. The enzymes used were Rhizopus arrhizus, Rhizopus delemar, and Candida cylindracea lipases and hog liver esterase. The hydrolability of these copolymers depends on the polymer composition, and is higher than that of both homopolymers. The hydrolysis products are 6-hydroxycaproic acid, lactic acid, and oligomers.

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Authors and Affiliations

  1. Dept. of Organic Materials, Osaka National Research Institute, AIST, 1-8-31 Midorigaoka, Ikeda, Osaka, 563, Japan

    Atsuyoshi Nakayama, Ioannis Arvanitoyannis, Norioki Kawasaki, Kazuko Hayashi & Noboru Yamamoto

Authors
  1. Atsuyoshi Nakayama
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  2. Ioannis Arvanitoyannis
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  3. Norioki Kawasaki
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  4. Kazuko Hayashi
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  5. Noboru Yamamoto
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102, Japan

    Naoya Ogata Ph.D. (Professor) (Professor)

  2. Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA

    Sung Wan Kim Ph.D. (Professor and Director) (Professor and Director)

  3. Department of Chemical Technology and Institute of Biomedical Technology, University of Twente, P.O. Box 217, 7500 AD, Enschede, The Netherlands

    Jan Feijen Ph.D. (Professor) (Professor)

  4. Institute of Biomedical Engineering, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162, Japan

    Teruo Okano Ph.D. (Professor) (Professor)

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© 1996 Springer-Verlag Tokyo

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Nakayama, A., Arvanitoyannis, I., Kawasaki, N., Hayashi, K., Yamamoto, N. (1996). Hydrolytic Degradation of Poly(L-Lactide-co-ε-Caprolactone)S. In: Ogata, N., Kim, S.W., Feijen, J., Okano, T. (eds) Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65883-2_57

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  • DOI: https://doi.org/10.1007/978-4-431-65883-2_57

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65885-6

  • Online ISBN: 978-4-431-65883-2

  • eBook Packages: Springer Book Archive

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