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Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems pp 71–75Cite as

Controlled Drug Delivery Formulation with Safe Polymers

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Summary

From the pharmaceutical point of view, the bioavailability, that is the amount and rate of absorption, is the most important factor determining the drug quality with respect to its efficacy and safety. Then, the bioavailability is controlled by well-designed dosage forms, for which interactions with surrounding components are applicable. Practically there are afforded various possibilities of modification of the interaction and then of control of drug delivery by a design of dosage forms, using polymers. The present talk will contain, as example, enteral delivery of insulin by Eudragit microsphere with protease inhibitors, topical mucosal drug delivery systems with adhesive polymers, and nasal delivery of salmon calcitonin by functional powder preparations using microcystalline cellulose. These polymers are guaranteed already as pharmaceutically safe ones.

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References

  1. Novel oral microspheres of insulin with protease inhibitor protecting from enzyme degradation: M. Morishita, I. Morishita, K. Takayama, Y. Machida and T. Nagai, Int. J. Pharm., 78, 1–7 (1992)

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  2. Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats: I. Morishita, M. Morishita, K. Takayama, Y. Machida and T. Nagai, Int. J. Pharm., 78, 9–16 (1992)

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  3. Enteral insulin delivery by microspheres in 3 different formulations using Eudragit L100 and S100: I. Morishita, M. Morishita, K. Takayama, Y. Machida and T. Nagai, Int. J. Pharm., 91, 29–37 (1993).

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  4. Adhesive topical drug delivery system: T. Nagai, J. Controlled Release, 2, 121 (1985)

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  5. Topical mucosal adhesive dosage forms: T. Nagai, Med. Res. Rev., 6, 227 (1986).

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  6. Therapeutic possibilities for nasal delivery: T. Nagai and Y. Suzuki, Topics in Pharmaceutical Sciences 1991 (Proceedings of the 51st International Congress of Pharmaceutical Sciences of FIP, Washington, D.C., USA, 1–6 September 1991), p.83–93 (1992)

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  7. Drug delivery to respiratory tracts by functional powder preparations: Y. Makino, K. Sakon, M. Dohi, M. Sakagami, Y. Nishibe, Proceedings of France-Japan DDS Symposium: Advances in Novel Science and Technology of Drug Delivery and Targeting, Hakone, Japan, 7–10, December, 1994, p11–12.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142, Japan

    Tsuneji Nagai

  2. Tsumura & Co., Yoshiwara 3586, Ami-machi, Inashiki-gun, Ibaraki, 300-11, Japan

    Mariko Morishita & Isao Morishita

  3. DDS Research Laboratories, Teijin Ltd., Asahigaoka 4-3-2, Hino, Tokyo 191, Japan

    Yoshiki Suzuki & Yuji Makino

Authors
  1. Tsuneji Nagai
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  2. Mariko Morishita
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  3. Isao Morishita
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  4. Yoshiki Suzuki
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  5. Yuji Makino
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102, Japan

    Naoya Ogata Ph.D. (Professor) (Professor)

  2. Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA

    Sung Wan Kim Ph.D. (Professor and Director) (Professor and Director)

  3. Department of Chemical Technology and Institute of Biomedical Technology, University of Twente, P.O. Box 217, 7500 AD, Enschede, The Netherlands

    Jan Feijen Ph.D. (Professor) (Professor)

  4. Institute of Biomedical Engineering, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162, Japan

    Teruo Okano Ph.D. (Professor) (Professor)

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© 1996 Springer-Verlag Tokyo

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Nagai, T., Morishita, M., Morishita, I., Suzuki, Y., Makino, Y. (1996). Controlled Drug Delivery Formulation with Safe Polymers. In: Ogata, N., Kim, S.W., Feijen, J., Okano, T. (eds) Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65883-2_14

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  • DOI: https://doi.org/10.1007/978-4-431-65883-2_14

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65885-6

  • Online ISBN: 978-4-431-65883-2

  • eBook Packages: Springer Book Archive

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