Skip to main content

Perinatal Coagulation and Fibrinolysis

  • Conference paper
Perinatal Thrombosis and Hemostasis

Abstract

In normal pregnancy extensive changes take place in the hemostatic system, involving in particular the coagulation and fibrinolytic systems. These physiological changes seem to have two major interrelated functions. First, to maintain the integrity of the expanding maternal and fetal circulations at the interface of the placenta and, secondly, to ensure the rapid and effective control of bleeding from the placental site during and after placental separation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sheppard B, Bonnar J (1974) The ultrastructure of the arterial supply of the human placenta in early and late pregnancy. J Obstet Gynaecol Br Cwlth 81: 497–511

    Article  CAS  Google Scholar 

  2. Bonnar J, McNicol GP, Douglas AS (1969) Fibrinolytic enzyme system and pregnancy. Br Med J 3: 387–395

    Article  PubMed  CAS  Google Scholar 

  3. MacFarlane RG, Biggs R (1946) Observations on fibrinolysis; spontaneous activity associated with surgical operations, trauma and c. Lancet II: 862–864

    Article  Google Scholar 

  4. Biezenski JJ, Moore HC (1958) Fibrinolysis in normal pregnancy. J Clin Pathol 11: 306–310

    Article  PubMed  CAS  Google Scholar 

  5. Shaper AG, Macintosh DM, Evans CM, Kyope J (1965) Fibrinolysis and plasminogen levels in pregnancy and the puerperium. Lancet II: 706–708

    Article  Google Scholar 

  6. Sheppard BL, Bonnar J (1976) The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation. Br J Obstet Gynaecol 83: 948–959

    Article  PubMed  CAS  Google Scholar 

  7. Sheppard BL, Bonnar J (1978) Fibrinolysis in decidual spiral arteries in late pregnancy. Thromb Haemost 39: 751–758

    PubMed  CAS  Google Scholar 

  8. Sheppard BL, Bonnar J (1981) An ultrastructural study of utero-placental spiral arteries in hypertensive and normotensive pregnancy and fetal growth retardation. Br J Obstet Gynaecol 88: 695–705

    Article  PubMed  CAS  Google Scholar 

  9. Sheppard BL, Boyle C, Gleeson N, Jordan M, Daly L, Bonnar J (1990) Plasminogen activator inhibitors of the placenta and placental bed at delivery in normotensive and hypertensive pregnancy. Placental communications. Biochem Morphol Cell Aspects 199: 151–159

    Google Scholar 

  10. Stirling Y, Woolf, L, North WRS, Seghatchian MJ, Meade TW (1984) Haemostasis in normal pregnancy. Thromb Haemost 52: 176–182

    PubMed  CAS  Google Scholar 

  11. Kawano T, Morimoto K, Uemura Y (1968) Urokinase inhibitor in human placenta. Nature 217: 253–254

    Article  PubMed  CAS  Google Scholar 

  12. Astedt B, Pandolphi M, Nilsson IM (1972) Inhibitory effect of placenta on plasminogen activation in human organ culture. Proc Soc Exp Biol Med 139: 1421–1424

    PubMed  CAS  Google Scholar 

  13. Astedt B, Hagerstrom I, Lecander I (1986) Cellular localisation in placenta of placental type plasminogen activator inhibitor. Thromb Haemost 56: 63–65

    PubMed  CAS  Google Scholar 

  14. Kruithof EKO, Tran-Thang C, Gudinchet A, Hauert J, Nicoloso G, Genton C, Welti H, Bachmann F (1987) Fibrinolysis in pregnancy: A study of plasminogen activator inhibitors. Blood 69: 460–466

    PubMed  CAS  Google Scholar 

  15. Lecander I, Astedt B (1986) Isolation of a new specific plasminogen activator inhibitor from pregnancy plasma. Br J Haematol 62: 221–228

    Article  PubMed  CAS  Google Scholar 

  16. Astedt B, Lecander I, Brondin T, Lundblad A, Low K (1985) Purification of a specific placental plasminogen activator by monoclonal antibody and its complex formation with plasminogen activator. Thromb Haemost 53: 122–125

    PubMed  CAS  Google Scholar 

  17. Astedt B, Lecander I, Ny T (1987) Review The placental type plasminogen activator inhibitor, PAI-2. Fibrinolysis 1: 203–208

    Google Scholar 

  18. Douglas JT, Shah M, Lowe GDO, Belch JJF, Forbes CD, Prentice CRM (1982) Plasma fibrinopeptide A and beta-thromboglobulin in pre-eclampsia and pregnancy hypertension. Thromb Haemost 47: 54–55

    PubMed  CAS  Google Scholar 

  19. Astedt B (1972) On fibrinolysis in pregnancy, labour, puerperium, and during treatment with sex hormones. Acta Obstet Gynecol Scand 51: (Suppl. 8): 1–24

    Article  Google Scholar 

  20. Bonnar J, McNicol GP, Douglas AS (1970) Coagulation and fibrinolytic mechanisms during and after normal childbirth. Br Med J 2: 200–203

    Article  PubMed  CAS  Google Scholar 

  21. Wiman B, Csemiczky, Marsk L, Robbe H (1984) The fast inhibitor of tissue plasminogen activator in plasma during pregnancy. Thromb Haemost 52: 124–126

    PubMed  CAS  Google Scholar 

  22. Astedt B, Lecander I, Nilsson IM (1986) Depression of PA activity during pregnancy by the placenta inhibitor fibrinolysis. Proceedings of the eighth international congress on fibrinolysis, p. 185

    Google Scholar 

  23. Wright JG, Cooper P, Astedt B, Lecander I, Wilde JT, Preston FE, Greaves M (1988) Fibrinolysis during normal human pregnancy: complex inter-relationships between plasma levels of tissue plasminogen activator and inhibitors and the euglobulin clot lysis time. Br J Haematol 69: 253–258

    Article  PubMed  CAS  Google Scholar 

  24. Fletcher AP, Alkjaersig NK, Burstein R (1979) The influence of pregnancy upon blood coagulation and plasma fibrinolytic enzyme function. Am J Obstet Gynecol. 134: 743–751

    PubMed  CAS  Google Scholar 

  25. Gaffney PJ, Creighton LJ, Callus M, Thorpe R (1988) Monoclonal antibodies to cross-linked fibrin degradation products (XL-FDP) II. Evaluation in a variety of clinical conditions. Br J Haematol 68: 91–96

    Article  PubMed  CAS  Google Scholar 

  26. Astedt B, Bladh B, Christensen U, Lecander I (1985) Different inhibition of one and two chain tissue plasminogen activator by a placental inhibitor studied with two tripeptide-p-nitroanilide substrates. Scand J Clin Lab Invest 45: 429–435

    PubMed  CAS  Google Scholar 

  27. Bonnar J, McNicol GP, Douglas AS (1971) Coagulation and fibrinolytic systems in pre-eclampsia and eclampsia. Br Med J II: 12–16

    Article  Google Scholar 

  28. Howie PW, Prentice CRM, McNicol GP (1971) Coagulation, fibrinolysis and platental function in pre-eclampsia, essential hypertension, and placental insufficiency. J Obstet Gynaecol Br Cwlth 78: 992–1003

    Article  CAS  Google Scholar 

  29. Gow L, Campbell DM, Ogston D (1984) The fibrinolytic system in pre-eclampsia. J Clin Pathol 37: 56–58

    Article  PubMed  CAS  Google Scholar 

  30. Aznar J, Gilabert J, Estelies A, Espana F (1986) Finbrinolytic activity and Protein C in pre-eclampsia. Thromb Haemost 55: 314–317

    PubMed  CAS  Google Scholar 

  31. Estelies A, Gilabert J, Aznar J, Scheef RR (1988) Plasminogen activator inhibitors type 1 and type 2 (PAI-1 and PAI-2) in normal pregnancy and in patients with severe pre-eclampsia. Fibrinolysis 2: 162

    Google Scholar 

  32. Giles C (1982) Intravascular coagulation in gestational hypertension and pre-eclampsia: the value of haematological screening tests. Clin Lab Haematol 4: 351–358

    Article  PubMed  CAS  Google Scholar 

  33. Borok Z, Weitz J, Owen J, Auerbach M, Nossel HL (1984) Fibrinogen proteolysis and platelet alpha-granule release in pre-eclampsia/eclampsia. Blood 63: 525–531

    PubMed  CAS  Google Scholar 

  34. Daly L, Bonnar J (1989) Fibrinolytic activation and inhibition in normal pregnancy and in pre-eclampsia. To be published

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Japan

About this paper

Cite this paper

Bonnar, J., Daly, L., Sheppard, B.L. (1991). Perinatal Coagulation and Fibrinolysis. In: Suzuki, S., Hathaway, W.E., Bonnar, J., Sutor, A.H. (eds) Perinatal Thrombosis and Hemostasis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65871-9_9

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-65871-9_9

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65873-3

  • Online ISBN: 978-4-431-65871-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics