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Nanoparticle Biomarkers Adapted for Near-Infrared Fluorescence Imaging

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System-Materials Nanoarchitectonics

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Abstract

We demonstrate recent advances in biomarkers of inorganic nanocrystals working in the near–infrared (NIR) wavelength range to highlight their potentials for in-vitro and in-vivo fluorescence imaging. Since inorganic nanocrystals are intrinsically stable against photo–irradiation and heat, biochemists expect to observe the long-term fluorescence of targeted cells or organs marked with biomarkers of inorganic nanocrystals. This chapter describes the recently developed NIR-light emitting biomarkers adapted for in-vitro and in-vivo imaging, and their toxicological study. At the end of this chapter, the last few years of progress in bioimaging will be outlined with possible future trends of NIR-light emitting biomarkers. It is also pointed out that the biomarkers of inorganic nanocrystals exhibit a potential risk associated with the accumulation of their constituent elements in organs. To minimize the risk, biocompatible inorganic nanocrystals are highlighted in this chapter. These biomarkers are expected to be used in various medical applications such as image-guided surgery for tumor removal and telemedicine for medication management.

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Authors and Affiliations

  1. International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1–1 Namiki, Tsukuba, 305-0044, Ibaraki, Japan

    Naoto Shirahata

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Correspondence to Naoto Shirahata .

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  1. National Institute for Materials Science, Tsukuba, Ibaraki, Japan

    Yutaka Wakayama

  2. National Institute for Materials Science, Tsukuba, Ibaraki, Japan

    Katsuhiko Ariga

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Shirahata, N. (2022). Nanoparticle Biomarkers Adapted for Near-Infrared Fluorescence Imaging. In: Wakayama, Y., Ariga, K. (eds) System-Materials Nanoarchitectonics. NIMS Monographs. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56912-1_3

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