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Molecular Soft-Interface Science pp 199–209Cite as

Nonprotein-Fouling, Hemocompatible, and Biospecific Surfaces Generated with Phospholipid Polymers

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Abstract

Protein adsorption is the first phenomenon that occurs when synthetic materials are exposed to a living organism. The uncontrolled (nonspecific) protein adsorption becomes a trigger for unfavorable foreign body reactions to the materials from a host. Suppression of nonspecific protein adsorption is quite important to prepare synthetic materials for biomedical applications. One of the most robust approaches is zwitterionic phosphorylcholine immobilization by a mimicking of biomembrane processes. The phosphatidylcholine surface of the biomembrane provides an inert surface for biological reactions of proteins and glycoproteins to occur smoothly on the membrane. This fact provides very significant information for the development of nonprotein-fouling surfaces. In this chapter, reliable methodologies for the creation of nonprotein-fouling and hemocompatible surfaces are described with a focus on 2-methacryloyloxyethyl phosphorylcholine (MPC).

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Authors and Affiliations

  1. Department of Chemistry and Materials Engineering, Kansai University, 3-3-35 Yamate-Cho, Suita-Shi, Osaka, 564-8680, Japan

    Yasuhiko Iwasaki

Authors
  1. Yasuhiko Iwasaki
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Correspondence to Yasuhiko Iwasaki .

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Editors and Affiliations

  1. RIKEN, Wako, Japan

    Mizuo Maeda

  2. Kyushu University, Fukuoka, Japan

    Atsushi Takahara

  3. Toyama University, Toyama, Japan

    Hiromi Kitano

  4. National Cerebral and Cardiovascular Cen, Suita, Japan

    Tetsuji Yamaoka

  5. Kyushu University, Fukuoka, Japan

    Yoshiko Miura

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Iwasaki, Y. (2019). Nonprotein-Fouling, Hemocompatible, and Biospecific Surfaces Generated with Phospholipid Polymers. In: Maeda, M., Takahara, A., Kitano, H., Yamaoka, T., Miura, Y. (eds) Molecular Soft-Interface Science. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56877-3_14

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