Current and Future Medical Treatment of Androgenetic Alopecia
The key change of androgenetic alopecia (AGA) is the thinning of hairs caused by miniaturization of hair follicles, not the shedding of hairs. As terminology implies, androgens (male sex hormones), especially dihydrotestosterone (DHT), play important roles in the pathogenesis of AGA, but no exact pathogenesis has been proven so far. However, several medications are successfully used for AGA through various mechanisms.
Many medical treatments for AGA have been introduced. Currently, oral 5AR inhibitors, including finasteride and dutasteride, and topical minoxidil are mainstream therapies. In addition, the topical 5AR inhibitor 17α-estradiol, mesotherapy, and LLLT can all be used as second-line treatments in some countries for both in men and women. Antiandrogens can be successfully used in females as well.
Cell-based treatment may be the future of medical treatment of hair loss, but more time is needed to establish effectiveness, cost, and technical details.
KeywordsAndrogenetic alopecia Current treatment Future treatment
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