Advertisement

Comments on Topical Formulations from a Medical Doctor

  • Akira KawadaEmail author
Chapter

Abstract

In the treatment of skin disease, topical drugs and cosmetic products are required. In particular, moisturizers that consist of occlusive, humectant, and emollient properties are frequently used in dermatological practice. In this review, the importance of the use of moisturizers in atopic dermatitis, senile xerosis, and acne vulgaris is discussed.

Keywords

Skin diseases Atopic dermatitis Senile xerosis Acne vulgaris Intercellular lipid Natural moisturizing factor Filaggrin Barrier Moisturizer Emollient Ceramide Urea 

References

  1. 1.
    Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (2000) High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest Dermatol 115(3):406–413CrossRefPubMedGoogle Scholar
  2. 2.
    Seguchi T, Cui CY, Kusuda S, Takahashi M, Aisu K, Tezuka T (1996) Decreased expression of filaggrin in atopic skin. Arch Dermatol Res 288(8):442–446CrossRefPubMedGoogle Scholar
  3. 3.
    Palmer CN, Irvine AD, Terron-Kwiatkowski A et al (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 38(4):441–446CrossRefPubMedGoogle Scholar
  4. 4.
    Osawa R, Akiyama M, Shimizu H (2011) Filaggrin gene defects and the risk of developing allergic disorders. Allergol Int 60(1):1–9CrossRefPubMedGoogle Scholar
  5. 5.
    Bissonnette R, Maari C, Provost N, Bolduc C, Nigen S, Rougier A, Seite S (2010) A double-blind study of tolerance and efficacy of a new urea-containing moisturizer in patients with atopic dermatitis. J Cosmet Dermatol 9(1):16–21CrossRefPubMedGoogle Scholar
  6. 6.
    Simpson E, Böhling A, Bielfeldt S, Bosc C, Kerrouche N (2013) Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor. J Dermatolog Treat 24(2):122–125CrossRefPubMedGoogle Scholar
  7. 7.
    Seghers AC, Cai SC, Ho MSL, Giam YC, Tan L, Grönhagen CM, Tang MBY (2014) Evaluation of pseudoceramide moisturizer in patients with mild-to-moderate atopic dermatitis. Dermatol Ther 4(1):83–92CrossRefGoogle Scholar
  8. 8.
    Simpson EL, Chalmers JR, Hanifin JM et al (2014) Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol 134(4):818–823CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Horimukai K, Morita K, Narita M et al (2014) Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol 134(4):824–830CrossRefPubMedGoogle Scholar
  10. 10.
    Takahashi M, Tezuka T (2004) The content of free amino acids in the stratum corneum is increased in senile xerosis. Arch Dermatol Res 295(10):448–452CrossRefPubMedGoogle Scholar
  11. 11.
    Hoffman L, Subramanyan K, Johnson AW, Tharp MD (2008) Benefits of an emollient body wash for patients with chronic winter dry skin. Dermatol Ther 21(5):416–421CrossRefPubMedGoogle Scholar
  12. 12.
    Baalham P, Birch I, Young M, Beale C (2011) Xerosis of the feet: a comparative study on the effectiveness of two moisturizers. Br J Community Nurs 16(12):591–592, 594–597Google Scholar
  13. 13.
    Christman JC, Fix DK, Lucus SC, Watson D, Desmier E, Wilkerson RJ, Fixler C (2012) Two randomized, controlled, comparative studies of the stratum corneum integrity benefits of tow cosmetic niacinamide/glycerin body moisturizers vs. conventional body moisturizers. J Drugs Dermatol 11(1):22–29PubMedGoogle Scholar
  14. 14.
    Kawada A (2007) Acne phototherapy: a new evolution for the treatment of acne vulgaris. Expert Rev Dermatol 2(1):1–3CrossRefGoogle Scholar
  15. 15.
    Chularojanamontri L, Tuchinda P, Kulthanan K, Pongparit K (2014) Moisturizers for acne. What are their constituents? J Clin Aesthet Dermatol 7(5):36–44PubMedPubMedCentralGoogle Scholar
  16. 16.
    Schorr ES, Sidou F, Kerrouche N (2012) Adjunctive use of a facial moisturizer SPF 30 containing ceramide precursor improves tolerability of topical tretinoin 0.05%: a randomized, investigator-blinded, split-face study. J Drugs Dermatol 11(9):1104–1107PubMedGoogle Scholar
  17. 17.
    Del Rosso JQ, Brandt S (2013) The role of skin care as an integral component in the management of acne vulgaris. Part 2: tolerability and performance of a designated skin care regimen using a foam wash and moisturizer SPF 30 in patients with acne vulgaris undergoing active treatment. J Clin Aesthet Dermatol 6(12):28–36PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Japan KK 2017

Authors and Affiliations

  1. 1.Department of DermatologyKindai University Faculty of MedicineOsaka-Sayama CityJapan

Personalised recommendations