Advertisement

Related Topic: Determination of Partition Coefficient from Vehicle to Skin

  • Yasuko ObataEmail author
  • Kozo Takayama
Chapter

Abstract

The first step of skin permeation of drugs is the distribution of drugs to the skin surface, the so-called “partition.” After that, partition and diffusion of drugs will be repeated via the stratum corneum, viable epidermis, and dermis. Consequently, the drug reaches the capillary system in subcutaneous tissue on its way toward the systemic circulation. The ratio of drug concentration between administrated vehicle and skin is defined as the “partition coefficient.” In transdermal drug delivery, increasing the partition coefficient is very important in order to increase in the amount of delivered drugs into the systemic circulation.

Keywords

Partition coefficient Diffusion coefficient Flux Thermodynamic activity Octanol Isopropyl myristate Stratum corneum Brick-mortal model Intercellular lipids Lamellar structure 

References

  1. 1.
    Bouwstra JA et al (1991) Structural investigations of human stratum corneum by small-angle X-ray scattering. J Invest Dermatol 97:1005–1012CrossRefPubMedGoogle Scholar
  2. 2.
    Bouwstra JA et al (1994) The lipid and protein structure of mouse stratum corneum: a wide and small angle diffraction study. Biochim Biophys Acta 1212:182–193Google Scholar
  3. 3.
    Kunii T et al (2003) Stratum corneum lipid profile and maturation pattern of corneocytes in the outermost layer of fresh scars: the presence of immature corneocytes plays a much more important role in the barrier dysfunction than do changes in intercellular lipids. Br J Dermatol 149:749–756CrossRefPubMedGoogle Scholar
  4. 4.
    Lieckfeldt R et al (1995) Apparent pKa of the fatty acids within ordered mixtures of model human stratum corneum lipids. Pharm Res 12:1614–1617CrossRefPubMedGoogle Scholar

Copyright information

© Springer Japan KK 2017

Authors and Affiliations

  1. 1.Department of PharmaceuticsHoshi UniversityTokyoJapan

Personalised recommendations